Immunogen sequence: NLQIPDPHLA DPSVLEALRQ KANFKHYKPK QFSMLEFLHR VGHDLKDMML YCKFKGQECG HQDFTTVFTK YGKCYMFNSG EDGKPLLTTV KGGTGNGLEI MLDIQQDEYL PIWGETEETT FEAGVKVQIH SQSEPPFIQE LGFGVAPGFQ TFVATQEQRL TYLPPPWGEC RSSEMGLDFF PVYSITACRI DCETRYIVEN CNCRMVHMPG DAPFCTPEQH KECAEPALGL LAEKDSNYCL CRTPCNLTRY NKELSMVKIP SKTSAKYLEK KFNKSEKYIS E; Positive Samples: U-251MG, 293T, Mouse brain, Rat brain, Rat lung; Cellular Location: Cell membrane, Multi-pass membrane protein
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.
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Protein Aliases: acid sensing (proton gated) ion channel 2; acid sensing ion channel 2; acid-sensing (proton-gated) ion channel 2; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Amiloride-sensitive cation channel neuronal 1; ASIC2; BNC1; Brain sodium channel 1; degenerin; Mammalian degenerin homolog; MDEG; neuronal amiloride-sensitive cation channel 1
Gene Aliases: ACCN; ACCN1; ACIC2; ASIC2; ASIC2a; BNAC1; BNaC1a; BNC1; BNC1k; hBNaC1; MDEG; MDEG1; MDEG2