Recommended positive controls: ASIC3 transfected cells and primary neuronal cells.
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
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Protein Aliases: acid sensing ion channel 3; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; ASIC3; Dorsal root ASIC; DRASIC; hASIC3; proton gated cation channel DRASIC
Gene Aliases: Accn3; Asic3; Drasic
UniProt ID: (Rat) O35240
Entrez Gene ID: (Rat) 286920