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Invitrogen
ASIC3 Polyclonal Antibody
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FIGURE: 1 / 3
ASIC3 Antibody (PA1-27981) in ICC/IF
Immunocytochemistry analysis of Dorsal Root Ganglia (DRGs) neurons using ASIC3 Polyclonal Antibody (Product # PA1-27981). Circle charts show the relative distribution of the three receptors among all DRG neurons. ASIC3 and P2X3 expression overlapped in only 4% of neurons, while some 35% of ASIC3-positive neurons also express TRPV1. Red: Primary antibody. Green: P2X3 (green, A) or TRPV1 (green, B).
Product Details
PA1-27981
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)TASLDPDDFDPEPSDPLGSP
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: ASIC3 transfected cells and primary neuronal cells.
Target Information
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acid sensing (proton gated) ion channel 3; acid sensing ion channel 3; acid-sensing (proton-gated) ion channel 3; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; amiloride-sensitive cation channel 3, testis; ASIC3; Dorsal root ASIC; DRASIC; hASIC3; hTNaC1; modulatory subunit of ASIC2a; Neuronal amiloride-sensitive cation channel 3; proton gated cation channel DRASIC; proton-gated cation channel subunit; Testis sodium channel 1
Gene Aliases: ACCN3; ASIC3; DRASIC; SLNAC1; TNAC1
UniProt ID: (Human) Q9UHC3, (Rat) O35240
Entrez Gene ID: (Human) 9311, (Rat) 286920
transport
signal transduction
sensory perception
response to heat
response to acidic pH
ion transmembrane transport
sodium ion transmembrane transport
enterobactin transport
sensory perception of sour taste
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
detection of chemical stimulus involved in sensory perception of pain
cation transport
sodium ion transport
response to mechanical stimulus
detection of chemical stimulus involved in sensory perception
detection of temperature stimulus involved in sensory perception
detection of mechanical stimulus involved in sensory perception
cation transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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