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Invitrogen
ASIC3 Polyclonal Antibody
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FIGURE: 1 / 3
ASIC3 Antibody (PA5-111817) in IHC (F)
Immunohistochemistry analysis of ASIC3 in perfusion-fixed, frozen mouse dorsal raphe nucleus tissue sections using ASIC3 Antibody (Product # PA5-111817) at a dilution of 1:200, followed by goat-anti-guinea pig-AlexaFluor-488 secondary antibody. ASIC3 staining (green) appears in the soma of dorsal raphe nucleus (DRN) neurons (arrows). Nuclei are stained with DAPI (blue).
Product Details
PA5-111817
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to amino acid residues 2-16 of rat ASIC3 (Intracellular, N-terminus)
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
Product Specific Information
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: KPRSGLEEAQ RRQAS(C)
Homology: Mouse - 14/15 amino acid residues identical; human - 11/15 amino acid residues identical.
Target Information
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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