Peptide sequence: VATFLYQVAE RVRYYREFHH QTALDERESH RLIFPAVTLC NINPLRRSRL
Sequence homology: Cow: 80%; Dog: 80%; Guinea Pig: 80%; Horse: 80%; Human: 100%; Mouse: 87%; Pig: 87%; Rabbit: 87%; Rat: 87%
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
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Protein Aliases: ACCN3; acid sensing (proton gated) ion channel 3; acid sensing ion channel 3; Acid-sensing (proton-gated) ion channel 3; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; amiloride-sensitive cation channel 3, testis; ASIC3; Dorsal root ASIC; DRASIC; hTNaC1; modulatory subunit of ASIC2a; Neuronal amiloride-sensitive cation channel 3; proton gated cation channel DRASIC; proton-gated cation channel subunit; SLNAC1; Testis sodium channel 1; TNaC1
Gene Aliases: ACCN3; ASIC3; AW742291; BOS_4613; DRASIC; SLNAC1; TNAC1