Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
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Protein Aliases: agouti signaling protein, nonagouti homolog; Agouti switch protein; Agouti-signaling protein; AGTI; AGTIL; ASP; nonagouti homolog
Gene Aliases: AGSW; AGTI; AGTIL; ASIP; ASP; SHEP9
UniProt ID: (Human) P42127
Entrez Gene ID: (Human) 434
Molecular Function: signaling molecule