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Invitrogen
ASIP Polyclonal Antibody
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FIGURE: 1 / 3
ASIP Antibody (PA5-77052) in WB
Nature metabolism 2022 -
Ectopic ASIP expression in patient-derived iPSCs persists during differentiation. a , ASIP expression in SVF cell-derived iPSCs from n = 3 clones (as biological independent samples) of the patient and n = 2 clones from each control (Ctr) 1 and 10. b , Immunoblot of ASIP in cell lysates and supernatants from untreated iPSCs from the patient and the two control children. Similar results were obtained by a sec... View More
Product Details
PA5-77052
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human ASIP.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: agouti signaling protein, nonagouti homolog; Agouti switch protein; Agouti-signaling protein; ASP; nonagouti homolog
Gene Aliases: AGSW; AGTI; AGTIL; ASIP; ASP; SHEP9
UniProt ID: (Human) P42127
Entrez Gene ID: (Human) 434
generation of precursor metabolites and energy
signal transduction
cell-cell signaling
adult feeding behavior
hormone-mediated signaling pathway
melanosome transport
melanosome organization
regulation of gene expression, epigenetic
melanin biosynthetic process
pigmentation
epigenetic programming in the zygotic pronuclei
positive regulation of melanin biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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