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Abnova
ASL Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 3
ASL Antibody (H00000435-D01P) in WB
Western Blot analysis of ASL expression in transfected 293T cell line (H00000435-T01) by ASL MaxPab polyclonal antibody.
Lane 1: ASL transfected lysate(51.70 KDa).
Lane 2: Non-transfected lysate.
Lane 1: ASL transfected lysate(51.70 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00000435-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ASL (NP_000039.2, 1 a.a. approximately 464 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MASESGKLWG GRFVGAVDPI MEKFNASIAY DRHLWEVDVQ GSKAYSRGLE KAGLLTKAEM DQILHGLDKV AEEWAQGTFK LNSNDEDIHT ANERRLKELI GATAGKLHTG RSRNDQVVTD LRLWMRQTCS TLSGLLWELI RTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSHAVAL TRDSERLLEV RKRINVLPLG SGAIAGNPLG VDRELLRAEL NFGAITLNSM DATSERDFVA EFLFWASLCM THLSRMAEDL ILYCTKEFSF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA GRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMS AVLQVATGVI STLQIHQENM GQALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVFMAET KGVALNQLSL QELQTISPLF SGDVICVWDY GHSVEQYGAL GGTARSSVDW QIRQVRALLQ AQQA
Target Information
ASL encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: argininosuccinase; Argininosuccinate lyase; argininosuccinate lyase (EC 4.3.2.1); Arginosuccinase; ASAL; unnamed protein product
Gene Aliases: 2510006M18Rik; ASAL; ASL
UniProt ID: (Human) P04424, (Mouse) Q91YI0
Entrez Gene ID: (Human) 435, (Mouse) 109900
urea cycle
cellular amino acid metabolic process
arginine metabolic process
arginine biosynthetic process
locomotory behavior
cellular amino acid biosynthetic process
post-embryonic development
ammonia assimilation cycle
arginine biosynthetic process via ornithine
positive regulation of nitric oxide biosynthetic process
L-amino acid metabolic process
argininosuccinate metabolic process
liver development
internal protein amino acid acetylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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