Product References
Role of asparagine biosynthesis pathway in Siniperca chuatsi rhabdovirus proliferation.
Frontiers in microbiology
Li F,Fu X,Luo X,Lin Q,Liang H,Niu Y,Liu L,Li N
Tue Apr 18 00:00:00 UTC 2023
Arginine limitation causes a directed DNA sequence evolution response in colorectal cancer cells.
bioRxiv : the preprint server for biology
Hsu DJ,Gao J,Yamaguchi N,Pinzaru A,Mandayam N,Liberti M,Heissel S,Alwaseem H,Tavazoie S,Tavazoie SF
Mon Jan 02 00:00:00 UTC 2023
Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells.
Science advances
Hsu DJ,Gao J,Yamaguchi N,Pinzaru A,Wu Q,Mandayam N,Liberti M,Heissel S,Alwaseem H,Tavazoie S,Tavazoie SF
Fri Jan 06 00:00:00 UTC 2023
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
EMBO molecular medicine
Southwell N,Primiano G,Nadkarni V,Attarwala N,Beattie E,Miller D,Alam S,Liparulo I,Shurubor YI,Valentino ML,Carelli V,Servidei S,Gross SS,Manfredi G,Chen Q,D'Aurelio M
Mon Jul 10 00:00:00 UTC 2023
Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR).
Molecular carcinogenesis
van der Mijn JC,Chen Q,Laursen KB,Khani F,Wang X,Dorsaint P,Sboner A,Gross SS,Nanus DM,Gudas LJ
Thu Sep 01 00:00:00 UTC 2022
Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR).
Molecular carcinogenesis
van der Mijn JC,Chen Q,Laursen KB,Khani F,Wang X,Dorsaint P,Sboner A,Gross SS,Nanus DM,Gudas LJ
Thu Sep 01 00:00:00 UTC 2022
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Molecular cell
Jiang B,Zhang J,Zhao G,Liu M,Hu J,Lin F,Wang J,Zhao W,Ma H,Zhang C,Wu C,Yao L,Liu Q,Chen X,Cao Y,Zheng Y,Zhang C,Han A,Lin D,Li Q
Thu May 19 00:00:00 UTC 2022
Asparagine bioavailability regulates the translation of MYC oncogene.
Oncogene
Srivastava S,Jiang J,Misra J,Seim G,Staschke KA,Zhong M,Zhou L,Liu Y,Chen C,Davé U,Kapur R,Batra S,Zhang C,Zhou J,Fan J,Wek RC,Zhang J
Sat Oct 01 00:00:00 UTC 2022
Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.
Science advances
Grima-Reyes M,Vandenberghe A,Nemazanyy I,Meola P,Paul R,Reverso-Meinietti J,Martinez-Turtos A,Nottet N,Chan WK,Lorenzi PL,Marchetti S,Ricci JE,Chiche J
Fri Jul 08 00:00:00 UTC 2022
Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein.
Frontiers in neurology
Höllerhage M,Stepath M,Kohl M,Pfeiffer K,Chua OWH,Duan L,Hopfner F,Eisenacher M,Marcus K,Höglinger GU
Sat Apr 30 00:00:00 UTC 2022
UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling.
Frontiers in immunology
Sancerni T,Renoult O,Luby A,Caradeuc C,Lenoir V,Croyal M,Ransy C,Aguilar E,Postic C,Bertho G,Dentin R,Prip-Buus C,Pecqueur C,Alves-Guerra MC
Tue Oct 25 00:00:00 UTC 2022
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
Cell death & disease
Ruan Y,Hu J,Che Y,Liu Y,Luo Z,Cheng J,Han Q,He H,Zhou Q
Wed Feb 16 00:00:00 UTC 2022
Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency.
The Journal of biological chemistry
Staklinski SJ,Chang MC,Yu F,Collins Ruff K,Franz DN,Qian Z,Bloom LB,Merritt ME,McKenna R,Kilberg MS
Thu Sep 01 00:00:00 UTC 2022
Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency.
The Journal of biological chemistry
Staklinski SJ,Chang MC,Yu F,Collins Ruff K,Franz DN,Qian Z,Bloom LB,Merritt ME,McKenna R,Kilberg MS
Thu Sep 01 00:00:00 UTC 2022
Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma.
Frontiers in oncology
Fu Y,Ding L,Yang X,Ding Z,Huang X,Zhang L,Chen S,Hu Q,Ni Y
Tue Mar 30 00:00:00 UTC 2021
A Novel Ferroptosis-Based Molecular Signature Associated with Biochemical Recurrence-Free Survival and Tumor Immune Microenvironment of Prostate Cancer.
Frontiers in cell and developmental biology
Ke ZB,You Q,Sun JB,Zhu JM,Li XD,Chen DN,Su L,Zheng QS,Wei Y,Xue XY,Xu N
Tue Jan 25 00:00:00 UTC 2022
Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress.
Frontiers in oncology
Okuda K,Umemura A,Kataoka S,Yano K,Takahashi A,Okishio S,Taketani H,Seko Y,Nishikawa T,Yamaguchi K,Moriguchi M,Nakagawa H,Liu Y,Mitsumoto Y,Kanbara Y,Shima T,Okanoue T,Itoh Y
Sat Nov 20 00:00:00 UTC 2021
Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms.
ACS pharmacology & translational science
Apfel V,Begue D,Cordo' V,Holzer L,Martinuzzi L,Buhles A,Kerr G,Barbosa I,Naumann U,Piquet M,Ruddy D,Weiss A,Ferretti S,Almeida R,Bonenfant D,Tordella L,Galli GG
Fri Feb 12 00:00:00 UTC 2021
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
Cell metabolism
Krall AS,Mullen PJ,Surjono F,Momcilovic M,Schmid EW,Halbrook CJ,Thambundit A,Mittelman SD,Lyssiotis CA,Shackelford DB,Knott SRV,Christofk HR
Tue May 04 00:00:00 UTC 2021
Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation.
Human molecular genetics
Vásquez-Trincado C,Patel M,Sivaramakrishnan A,Bekeová C,Anderson-Pullinger L,Wang N,Tang HY,Seifert EL
Wed Sep 22 00:00:00 UTC 2021
Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase.
Pharmacology
Wang S,Ding Y,Dong R,Wang H,Yin L,Meng S
Wed Jan 26 00:00:00 UTC 2022
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer.
The Journal of experimental medicine
Recouvreux MV,Moldenhauer MR,Galenkamp KMO,Jung M,James B,Zhang Y,Lowy A,Bagchi A,Commisso C
Mon Sep 07 00:00:00 UTC 2020
Glutamine and asparagine activate mTORC1 independently of Rag GTPases.
The Journal of biological chemistry
Meng D,Yang Q,Wang H,Melick CH,Navlani R,Frank AR,Jewell JL
Fri Mar 06 00:00:00 UTC 2020
JMJD2B-induced amino acid alterations enhance the survival of colorectal cancer cells under glucose-deprivation via autophagy.
Theranostics
Tan J,Wang HL,Yang J,Liu QQ,Li CM,Wang YQ,Fu LN,Gao QY,Chen YX,Fang JY
Mon Aug 02 00:00:00 UTC 2021
ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase.
Cell metabolism
Williams RT,Guarecuco R,Gates LA,Barrows D,Passarelli MC,Carey B,Baudrier L,Jeewajee S,La K,Prizer B,Malik S,Garcia-Bermudez J,Zhu XG,Cantor J,Molina H,Carroll T,Roeder RG,Abdel-Wahab O,Allis CD,Birsoy K
Tue Apr 07 00:00:00 UTC 2020
p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival.
Nature communications
Deng L,Yao P,Li L,Ji F,Zhao S,Xu C,Lan X,Jiang P
Thu Apr 09 00:00:00 UTC 2020
Suppression of asparagine synthetase enhances the antitumor potency of ART and artemalogue SOMCL-14-221 in non-small cell lung cancer.
Cancer letters
Xiao R,Ding C,Zhu H,Liu X,Gao J,Liu Q,Lu D,Zhang N,Zhang A,Zhou H
Fri Apr 10 00:00:00 UTC 2020
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion.
The Journal of biological chemistry
Jiang J,Srivastava S,Seim G,Pavlova NN,King B,Zou L,Zhang C,Zhong M,Feng H,Kapur R,Wek RC,Fan J,Zhang J
Fri Dec 06 00:00:00 UTC 2019
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer.
Cell reports
Lukey MJ,Cluntun AA,Katt WP,Lin MJ,Druso JE,Ramachandran S,Erickson JW,Le HH,Wang ZE,Blank B,Greene KS,Cerione RA
Tue Oct 01 00:00:00 UTC 2019
Asparagine Is a Critical Limiting Metabolite for Vaccinia Virus Protein Synthesis during Glutamine Deprivation.
Journal of virology
Pant A,Cao S,Yang Z
Mon Jul 01 00:00:00 UTC 2019
Amino acids signatures of distance-related surgical margins of oral squamous cell carcinoma.
EBioMedicine
Yang XH,Zhang XX,Jing Y,Ding L,Fu Y,Wang S,Hu SQ,Zhang L,Huang XF,Ni YH,Hu QG
Tue Oct 01 00:00:00 UTC 2019
Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication.
mBio
Lee CH,Griffiths S,Digard P,Pham N,Auer M,Haas J,Grey F
Tue Oct 08 00:00:00 UTC 2019
The landscape of cancer cell line metabolism.
Nature medicine
Li H,Ning S,Ghandi M,Kryukov GV,Gopal S,Deik A,Souza A,Pierce K,Keskula P,Hernandez D,Ann J,Shkoza D,Apfel V,Zou Y,Vazquez F,Barretina J,Pagliarini RA,Galli GG,Root DE,Hahn WC,Tsherniak A,Giannakis M,Schreiber SL,Clish CB,Garraway LA,Sellers WR
Wed May 01 00:00:00 UTC 2019
The landscape of cancer cell line metabolism.
Nature medicine
Li H,Ning S,Ghandi M,Kryukov GV,Gopal S,Deik A,Souza A,Pierce K,Keskula P,Hernandez D,Ann J,Shkoza D,Apfel V,Zou Y,Vazquez F,Barretina J,Pagliarini RA,Galli GG,Root DE,Hahn WC,Tsherniak A,Giannakis M,Schreiber SL,Clish CB,Garraway LA,Sellers WR
Wed May 01 00:00:00 UTC 2019
Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis.
Autophagy
Lin HH,Chung Y,Cheng CT,Ouyang C,Fu Y,Kuo CY,Chi KK,Sadeghi M,Chu P,Kung HJ,Li CF,Limesand KH,Ann DK
Tue Oct 15 00:00:00 UTC 2019
Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction.
Communications biology
Cheng CT,Qi Y,Wang YC,Chi KK,Chung Y,Ouyang C,Chen YR,Oh ME,Sheng X,Tang Y,Liu YR,Lin HH,Kuo CY,Schones D,Vidal CM,Chu JC,Wang HJ,Chen YH,Miller KM,Chu P,Yen Y,Jiang L,Kung HJ,Ann DK
Sat Jan 11 00:00:00 UTC 2020
Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction.
Communications biology
Cheng CT,Qi Y,Wang YC,Chi KK,Chung Y,Ouyang C,Chen YR,Oh ME,Sheng X,Tang Y,Liu YR,Lin HH,Kuo CY,Schones D,Vidal CM,Chu JC,Wang HJ,Chen YH,Miller KM,Chu P,Yen Y,Jiang L,Kung HJ,Ann DK
Sat Jan 11 00:00:00 UTC 2020
Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.
Cell reports
Kremer JC,Prudner BC,Lange SES,Bean GR,Schultze MB,Brashears CB,Radyk MD,Redlich N,Tzeng SC,Kami K,Shelton L,Li A,Morgan Z,Bomalaski JS,Tsukamoto T,McConathy J,Michel LS,Held JM,Van Tine BA
Tue Jan 24 00:00:00 UTC 2017
Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.
Cell reports
Kremer JC,Prudner BC,Lange SES,Bean GR,Schultze MB,Brashears CB,Radyk MD,Redlich N,Tzeng SC,Kami K,Shelton L,Li A,Morgan Z,Bomalaski JS,Tsukamoto T,McConathy J,Michel LS,Held JM,Van Tine BA
Tue Jan 24 00:00:00 UTC 2017
Loss of asparagine synthetase suppresses the growth of human lung cancer cells by arresting cell cycle at G0/G1 phase.
Cancer gene therapy
Xu Y,Lv F,Zhu X,Wu Y,Shen X
Thu Sep 01 00:00:00 UTC 2016
Loss of asparagine synthetase suppresses the growth of human lung cancer cells by arresting cell cycle at G0/G1 phase.
Cancer gene therapy
Xu Y,Lv F,Zhu X,Wu Y,Shen X
Thu Sep 01 00:00:00 UTC 2016
Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells.
Biotechnology and applied biochemistry
Li H,Zhou F,Du W,Dou J,Xu Y,Gao W,Chen G,Zuo X,Sun L,Zhang X,Yang S
Sun May 01 00:00:00 UTC 2016
Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells.
Biotechnology and applied biochemistry
Li H,Zhou F,Du W,Dou J,Xu Y,Gao W,Chen G,Zuo X,Sun L,Zhang X,Yang S
Sun May 01 00:00:00 UTC 2016
Transcriptome Analysis of Piperlongumine-Treated Human Pancreatic Cancer Cells Reveals Involvement of Oxidative Stress and Endoplasmic Reticulum Stress Pathways.
Journal of medicinal food
Dhillon H,Mamidi S,McClean P,Reindl KM
Wed Jun 01 00:00:00 UTC 2016
Transcriptome Analysis of Piperlongumine-Treated Human Pancreatic Cancer Cells Reveals Involvement of Oxidative Stress and Endoplasmic Reticulum Stress Pathways.
Journal of medicinal food
Dhillon H,Mamidi S,McClean P,Reindl KM
Wed Jun 01 00:00:00 UTC 2016
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.
Nature communications
Krall AS,Xu S,Graeber TG,Braas D,Christofk HR
Fri Apr 29 00:00:00 UTC 2016
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.
Nature communications
Krall AS,Xu S,Graeber TG,Braas D,Christofk HR
Fri Apr 29 00:00:00 UTC 2016
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Molecular cell
Zhang J,Fan J,Venneti S,Cross JR,Takagi T,Bhinder B,Djaballah H,Kanai M,Cheng EH,Judkins AR,Pawel B,Baggs J,Cherry S,Rabinowitz JD,Thompson CB
Thu Oct 23 00:00:00 UTC 2014
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Molecular cell
Zhang J,Fan J,Venneti S,Cross JR,Takagi T,Bhinder B,Djaballah H,Kanai M,Cheng EH,Judkins AR,Pawel B,Baggs J,Cherry S,Rabinowitz JD,Thompson CB
Thu Oct 23 00:00:00 UTC 2014
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Molecular cell
Zhang J,Fan J,Venneti S,Cross JR,Takagi T,Bhinder B,Djaballah H,Kanai M,Cheng EH,Judkins AR,Pawel B,Baggs J,Cherry S,Rabinowitz JD,Thompson CB
Thu Oct 23 00:00:00 UTC 2014
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Molecular cell
Zhang J,Fan J,Venneti S,Cross JR,Takagi T,Bhinder B,Djaballah H,Kanai M,Cheng EH,Judkins AR,Pawel B,Baggs J,Cherry S,Rabinowitz JD,Thompson CB
Thu Oct 23 00:00:00 UTC 2014
Down-regulation of asparagine synthetase induces cell cycle arrest and inhibits cell proliferation of breast cancer.
Chemical biology & drug design
Yang H,He X,Zheng Y,Feng W,Xia X,Yu X,Lin Z
Sat Nov 01 00:00:00 UTC 2014
Down-regulation of asparagine synthetase induces cell cycle arrest and inhibits cell proliferation of breast cancer.
Chemical biology & drug design
Yang H,He X,Zheng Y,Feng W,Xia X,Yu X,Lin Z
Sat Nov 01 00:00:00 UTC 2014