This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Abnormal spindle protein homolog; Abnormal spindle-like microcephaly-associated protein; asp (abnormal spindle) homolog, microcephaly associated; Asp homolog
Gene Aliases: ASP; ASPM; Calmbp1; MCPH5
UniProt ID: (Human) Q8IZT6
Entrez Gene ID: (Human) 259266