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ASPP2/p53BP2 Polyclonal Antibody
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Product Details
BS-1283R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ASPP2, amino acids 1001-1128.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 53BP2; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; Bbp; BCL2-binding protein; P PPP1R13A; Renal carcinoma antigen NY-REN-51; transformation related protein 53 binding protein 2; tumor protein p53 binding protein, 2; Tumor suppressor p53-binding protein 2; unnamed protein product
Gene Aliases: 53BP2; ASPP2; BBP; P53BP2; PPP1R13A; TP53BP2; Trp53bp2
UniProt ID: (Human) Q13625
Entrez Gene ID: (Human) 7159, (Rat) 305025
apoptotic process
signal transduction
regulation of apoptotic process
negative regulation of cell cycle
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of execution phase of apoptosis
central nervous system development
heart development
biological_process
embryo development ending in birth or egg hatching
response to ionizing radiation
positive regulation of neuron death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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