Immunogen sequence: RGEALGVYNR LSPQDQGDYG TVKEALLKAF GVPGAAPSHL PKEIVFANSM
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Predicted homology: Guinea Pig: 92%; Horse: 100%; Human: 100%; Rat: 93%
Filaggrin is a structural protein that is crucial for in the development and maintenance of the skin barrier. This gene encodes a retroviral-like protease involved in profilaggrin-to-filaggrin processing. Expression is found primarily in the epidermis and inner root sheath of hair follicles.
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Protein Aliases: ASPRV1; Retroviral-like aspartic protease 1; SASPase; skin aspartic protease; Skin-specific retroviral-like aspartic protease; TAPS; TPA-inducible aspartic proteinase-like protein
Gene Aliases: ASPRV1; MUNO; SASP; SASPase; Taps
UniProt ID: (Human) Q53RT3
Entrez Gene ID: (Human) 151516
Molecular Function: viral or transposable element protein