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Fabgennix
ASXL1 Polyclonal Antibody, FITC
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Product Details
ASXL1-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 1120-1180 on mouse Putative Polycomb group protein ASXL1.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
proprietary buffer with 30% glycerol
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: additional sex combs like 1; Additional sex combs-like protein 1; MGC117280; MGC71111; Polycomb group protein ASXL1; putative Polycomb group protein ASXL1
Gene Aliases: Asxl1; Kiaa0978; mKIAA0978; RGD1561878
UniProt ID: (Mouse) P59598
Entrez Gene ID: (Mouse) 228790, (Rat) 311553
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
response to retinoic acid
negative regulation of peroxisome proliferator activated receptor signaling pathway
monoubiquitinated histone H2A deubiquitination
negative regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of retinoic acid receptor signaling pathway
negative regulation of retinoic acid receptor signaling pathway
bone development
lung saccule development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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