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Invitrogen
ASXL1 Polyclonal Antibody
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FIGURE: 1 / 1
ASXL1 Antibody (PA5-68360) in IHC (P)
Immunohistochemical analysis of ASXL1 in paraffin-embedded Human esophagus cancer tissue using (left) ASXL1 Polyclonal Antibody (Product # PA5-68360). at a 1:45 dilution and (right) is treated with synthetic peptide. (Original magnification: x200).
Product Details
PA5-68360
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human ASXL1.
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Amount
110 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse samples.
Target Information
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: additional sex combs like 1, transcriptional regulator; additional sex combs like transcriptional regulator 1; Additional sex combs-like protein 1; MGC117280; MGC71111; Polycomb group protein ASXL1; putative Polycomb group protein ASXL1; unnamed protein product
Gene Aliases: ASXL1; BOPS; KIAA0978; MDS; mKIAA0978
UniProt ID: (Human) Q8IXJ9, (Mouse) P59598
Entrez Gene ID: (Human) 171023, (Mouse) 228790
cell morphogenesis
heart morphogenesis
chromatin organization
regulation of transcription, DNA-templated
organ morphogenesis
hemopoiesis
response to retinoic acid
negative regulation of peroxisome proliferator activated receptor signaling pathway
regulation of kidney size
negative regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of retinoic acid receptor signaling pathway
hematopoietic or lymphoid organ development
thymus development
bone marrow development
homeostasis of number of cells
bone development
lung saccule development
glomerular visceral epithelial cell development
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
chromatin modification
monoubiquitinated histone H2A deubiquitination
negative regulation of retinoic acid receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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