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Fabgennix
ASXL2 Polyclonal Antibody, Biotin
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Product Details
ASXL2-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 1200-1275 on mouse Putative Polycomb group protein ASXL2.
Conjugate
Form
Liquid
Concentration
0.5-1.5 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
proprietary buffer with 30% glycerol
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: additional sex combs like 2; additional sex combs like 2, transcriptional regulator; additional sex combs like transcriptional regulator 2; Additional sex combs-like protein 2; polycomb group protein ASXH2; polycomb group protein ASXH2 homolog; Putative Polycomb group protein ASXL2; unnamed protein product
Gene Aliases: 4930556B16Rik; ASXH2; ASXL2; KIAA1685; mKIAA1685; SHAPNS
UniProt ID: (Human) Q76L83, (Mouse) Q8BZ32
Entrez Gene ID: (Human) 55252, (Mouse) 75302, (Rat) 313922
regulation of transcription, DNA-templated
organ morphogenesis
positive regulation of peroxisome proliferator activated receptor signaling pathway
positive regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
transcription, DNA-templated
heart development
adult heart development
positive regulation of osteoclast differentiation
embryonic skeletal system morphogenesis
positive regulation of bone mineralization involved in bone maturation
positive regulation of histone H3-K27 trimethylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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