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Proteintech
ASZ1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
21550-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ASZ1 Fusion Protein Ag16217 (20-372 aa encoded by BC034963)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SEDDGWEIG YLDRTSQKLK RLLPIEEKKE KFKKAMTIGD VSLVQELLDS GISVDSNFQY GWTPLMYAAS VANAELVRVL LDRGANASFE KDKQSILITA CSAHGSEEQI LKCVELLLSR NADPNVACRR LMTPIMYAAR DGHTQVVALL VAHGAEVNTQ DENGYTALTW AARQGHKNIV LKLLELGANK MLQTKDGKMP SEIAKRNKHH EIFNLLSFTL NPLEGKLQQL TKEDTICKIL TTDSDREKDH IFSSYTAFGD LEVFLHGLGL EHMTDLLKER DITLRHLLTM REDEFTKNGI TSKDQQKILA ALKELQVEEI QFGELSEETK LEISGDEFLN FLLKLNKQCG HLIT (20-372 aa encoded by BC034963)
Target Information
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ankyrin-like 1; ankyrin-like protein 1; germ cell-specific ankyrin, SAM and basic leucine zipper domain containing protein; germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein; may mediate protein-protein interactions; unnamed protein product
Gene Aliases: 4933400N19Rik; ALP1; ANKL1; C7orf7; CT1.19; GASZ; ORF3
UniProt ID: (Human) Q8WWH4, (Mouse) Q8VD46
Entrez Gene ID: (Human) 136991, (Rat) 170578, (Mouse) 74068
male meiosis
spermatogenesis
negative regulation of transposition, RNA-mediated
positive regulation of endothelial cell proliferation
positive regulation of mesenchymal cell proliferation
cell-cell signaling
positive regulation of cell proliferation
Wnt signaling pathway
lung development
cell proliferation in midbrain
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
animal organ development
system development
positive regulation of neurogenesis
atrial cardiac muscle tissue morphogenesis
positive regulation of cardiac muscle cell proliferation
canonical Wnt signaling pathway
cardiac epithelial to mesenchymal transition
lung induction
positive regulation of epithelial cell proliferation involved in lung morphogenesis
labyrinthine layer blood vessel development
mammary gland epithelium development
cellular response to transforming growth factor beta stimulus
midbrain dopaminergic neuron differentiation
germ cell development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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