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7TM Antibodies
AT2 (Angiotensin Receptor 2) Polyclonal Antibody
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FIGURE: 1 / 1
AT2 (Angiotensin Receptor 2) Antibody (7TM0035N) in WB
Validation of the Angiotensin Receptor 2 in transfected HEK293 cells. Native HEK293 cells (MOCK) or HEK293 cells stably expressing the Angiotensin Receptor 2 (AT2) were lysed and immunoblotted with the phosphorylation-independent anti-AT2 antibody (7TM0035N) at a dilution of 1:1,000.
Product Details
7TM0035N
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide presents the carboxyl-terminal tail of human AT2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AGTR2; Angiotensin ii at2; Angiotensin II type-2 receptor; AT2 receptor; Type-2 angiotensin II receptor; unnamed protein product
Gene Aliases: AGTR2; AT2; ATGR2; MRX88
UniProt ID: (Human) P50052
Entrez Gene ID: (Human) 186
blood vessel remodeling
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
brain renin-angiotensin system
inflammatory response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
brain development
regulation of blood pressure
negative regulation of heart rate
negative regulation of cell growth
regulation of metanephros size
exploration behavior
nitric oxide-cGMP-mediated signaling pathway
angiotensin-activated signaling pathway
vasodilation
regulation of apoptotic process
negative regulation of blood vessel endothelial cell migration
positive regulation of transcription, DNA-templated
negative regulation of neurotrophin TRK receptor signaling pathway
neuron apoptotic process
positive regulation of metanephric glomerulus development
positive regulation of branching involved in ureteric bud morphogenesis
regulation of blood vessel diameter
positive regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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