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Invitrogen
ATF1 Polyclonal Antibody
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FIGURE: 1 / 1
ATF1 Antibody (PA5149533) in ChIP
ChIP Assay of ATF1 in K562 cells. ChIP-Exo-Seq composite graph for ATF1 polyclonal antibody (Product # PA5149533). Strand-specific reads (blue: forward, red: reverse) and IgG controls (black: forward, grey: reverse) are plotted against the distance from a composite set of reference binding sites. The antibody exhibits robust target enrichment compared to a non-specific IgG control and precisely reveals its structural organization around the binding site.
Product Details
PA5149533
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ATF1
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TYQIRTTPSA TSLPQTVVMT SPVTLTSQTT KTDD
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
Target Information
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activating transcription factor 1; cAMP-dependent transcription factor ATF-1; Cyclic AMP-dependent transcription factor ATF-1; Protein TREB36; unnamed protein product
Gene Aliases: ATF1; EWS-ATF1; FUS/ATF-1; TREB36
UniProt ID: (Human) P18846
Entrez Gene ID: (Human) 466
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
sequence-specific DNA binding
macromolecular complex binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of neuron projection development
response to purine-containing compound
response to cobalt ion
positive regulation of DNA replication
positive regulation of transcription from RNA polymerase II promoter
protein-containing complex assembly
cAMP/PKA signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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