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Invitrogen

ATF2 Polyclonal Antibody

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ATF2 Polyclonal Antibody

Product Details

PA5-86110

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunoprecipitation (IP)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 20-70 of Human ATF2.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2802909

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activating 2; Activating transcription factor 2; ATF2; bZIP transcription factor; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; CREB-2; cyclic AMP response element-binding protein (HB16); Cyclic AMP-dependent transcription factor ATF-2; Cyclic AMP-responsive element-binding protein 2; HB16; histone acetyltransferase ATF2; MGC111558; MXBP protein; OTTHUMP00000205345; OTTHUMP00000205347; OTTHUMP00000205348; OTTHUMP00000205350; OTTHUMP00000205352; OTTHUMP00000205353; OTTHUMP00000205354; unnamed protein product

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Gene Aliases: Atf-2; ATF2; CRE-BP; CRE-BP1; CREB-2; CREB2; CREBP1; D130078H02Rik; D18875; HB16; mXBP; Tg(Gzma-Klra1)7Wum; TREB7

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UniProt ID: (Human) P15336, (Rat) Q00969, (Mouse) P16951

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Entrez Gene ID: (Human) 1386, (Rat) 81647, (Mouse) 11909

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding histone acetyltransferase activity protein binding cAMP response element binding protein binding zinc ion binding H4 histone acetyltransferase activity protein kinase binding cAMP response element binding identical protein binding protein homodimerization activity leucine zipper domain binding sequence-specific DNA binding histone H2B acetyltransferase activity metal ion binding protein heterodimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding enhancer sequence-specific DNA binding nucleic acid binding transferase activity basic leucine zipper transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade in utero embryonic development NK T cell differentiation liver development hematopoietic progenitor cell differentiation outflow tract morphogenesis brainstem development growth plate cartilage chondrocyte differentiation growth plate cartilage chondrocyte proliferation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein import into nucleus lipid metabolic process apoptotic process response to osmotic stress cellular response to DNA damage stimulus vacuole organization JNK cascade heart development gene expression positive regulation of gene expression negative regulation of angiogenesis peptidyl-threonine phosphorylation abducens nucleus development hypoglossal nucleus development facial nucleus development BMP signaling pathway intra-S DNA damage checkpoint positive regulation of transforming growth factor beta2 production cellular response to oxidative stress p38MAPK cascade mRNA transcription from RNA polymerase II promoter positive regulation of gene expression, epigenetic positive regulation of transcription from RNA polymerase II promoter white fat cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity neurofilament cytoskeleton organization detection of cell density adipose tissue development cellular response to anisomycin motor neuron apoptotic process hepatocyte apoptotic process cellular response to virus positive regulation of cardiac muscle myoblast proliferation positive regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process involved in development intrinsic apoptotic signaling pathway in response to hypoxia cellular response to leucine starvation transcription, DNA-templated transcription from RNA polymerase II promoter histone acetylation fat cell differentiation
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