Product References
Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver-Resident Macrophage M2 Polarization via C/EBP Homologous Protein-Mediated Endoplasmic Reticulum Stress.
Frontiers in immunology
Rao Z,Sun J,Pan X,Chen Z,Sun H,Zhang P,Gao M,Ding Z,Liu C
Sun Apr 10 00:00:00 EDT 2022
ATF4 Involvement in TLR4 and LOX-1-Induced Host Inflammatory Response to Aspergillus fumigatus Keratitis.
Journal of ophthalmology
Zhang S,Meng P,Liu G,Liu K,Che C
Thu Mar 31 00:00:00 EDT 2022
ATF4 Involvement in TLR4 and LOX-1-Induced Host Inflammatory Response to Aspergillus fumigatus Keratitis.
Journal of ophthalmology
Zhang S,Meng P,Liu G,Liu K,Che C
Thu Mar 31 00:00:00 EDT 2022
Exogenous H2S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Cell & bioscience
Sun W,Yang J,Zhang Y,Xi Y,Wen X,Yuan D,Wang Y,Wei C,Wang R,Wu L,Li H,Xu C
Fri Mar 11 00:00:00 EST 2022
eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.
Nutrition & metabolism
Choi WG,Han J,Kim JH,Kim MJ,Park JW,Song B,Cha HJ,Choi HS,Chung HT,Lee IK,Park TS,Hatzoglou M,Choi HS,Yoo HJ,Kaufman RJ,Back SH
Thu Oct 01 00:00:00 EDT 2020
Differentially expressed genes of HepG2 cells treated with gecko polypeptide mixture.
Journal of Cancer
Duan YM,Jin Y,Guo ML,Duan LX,Wang JG
Wed Sep 30 00:00:00 EDT 2020
20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway.
Journal of cellular biochemistry
Wang X,Xia HY,Qin HY,Kang XP,Hu HY,Zheng J,Jiang JY,Yao LA,Xu YW,Zhang T,Zhang XL
Mon Apr 01 00:00:00 EDT 2019
Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice.
British journal of pharmacology
Gu M,Zhao P,Zhang S,Fan S,Yang L,Tong Q,Ji G,Huang C
Mon Apr 01 00:00:00 EDT 2019
Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice.
British journal of pharmacology
Gu M,Zhao P,Zhang S,Fan S,Yang L,Tong Q,Ji G,Huang C
Mon Apr 01 00:00:00 EDT 2019
Efficient RNA interference-based knockdown of mutant torsinA reveals reversibility of PERK-eIF2α pathway dysregulation in DYT1 transgenic rats in vivo.
Brain research
Beauvais G,Watson JL,Aguirre JA,Tecedor L,Ehrlich ME,Gonzalez-Alegre P
Fri Mar 01 00:00:00 EST 2019
Icariside II prevents hypertensive heart disease by alleviating endoplasmic reticulum stress via the PERK/ATF-4/CHOP signalling pathway in spontaneously hypertensive rats.
The Journal of pharmacy and pharmacology
Wu Y,Yue Y,Fu S,Li Y,Wu D,Lv J,Yang D
Fri Mar 01 00:00:00 EST 2019
Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1.
Autophagy
Sun P,Zhang S,Qin X,Chang X,Cui X,Li H,Zhang S,Gao H,Wang P,Zhang Z,Luo J,Li Z
Tue Feb 26 00:00:00 EST 2019
Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1.
Autophagy
Sun P,Zhang S,Qin X,Chang X,Cui X,Li H,Zhang S,Gao H,Wang P,Zhang Z,Luo J,Li Z
Tue Feb 26 00:00:00 EST 2019
Sigma-1 receptor protects against endoplasmic reticulum stress-mediated apoptosis in mice with cerebral ischemia/reperfusion injury.
Apoptosis : an international journal on programmed cell death
Zhao X,Zhu L,Liu D,Chi T,Ji X,Liu P,Yang X,Tian X,Zou L
Fri Feb 01 00:00:00 EST 2019
IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages.
Immunology and cell biology
Ayaub EA,Tandon K,Padwal M,Imani J,Patel H,Dubey A,Mekhael O,Upagupta C,Ayoub A,Dvorkin-Gheva A,Murphy J,Kolb PS,Lhotak S,Dickhout JG,Austin RC,Kolb MRJ,Richards CD,Ask K
Fri Feb 01 00:00:00 EST 2019
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
In vitro cellular & developmental biology. Animal
Ullah O,Li Z,Ali I,Xu L,Liu H,Jin HZ,Fang YY,Jin QG,Fang N
Fri Feb 01 00:00:00 EST 2019
Methane-Rich Saline Ameliorates Sepsis-Induced Acute Kidney Injury through Anti-Inflammation, Antioxidative, and Antiapoptosis Effects by Regulating Endoplasmic Reticulum Stress.
Oxidative medicine and cellular longevity
Jia Y,Li Z,Feng Y,Cui R,Dong Y,Zhang X,Xiang X,Qu K,Liu C,Zhang J
Tue Jan 22 00:00:00 EST 2019
Autophagy activation alleviates nonylphenol-induced apoptosis in cultured cortical neurons.
Neurochemistry international
Li S,Jiang Z,Chai W,Xu Y,Wang Y
Tue Jan 01 00:00:00 EST 2019
Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity.
The Science of the total environment
Li P,Liu L,Zhou G,Tian Z,Luo C,Xia T,Chen J,Niu Q,Dong L,Zhao Q,Wang A,Zhang S
Sat Dec 15 00:00:00 EST 2018
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
International immunopharmacology
Wang D,Lao L,Pang X,Qiao Q,Pang L,Feng Z,Bai F,Sun X,Lin X,Wei J
Sat Dec 01 00:00:00 EST 2018
Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis.
International journal of molecular sciences
Wang SF,Wung CH,Chen MS,Chen CF,Yin PH,Yeh TS,Chang YL,Chou YC,Hung HH,Lee HC
Mon Oct 29 00:00:00 EDT 2018
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Oxidative medicine and cellular longevity
Maryam A,Mehmood T,Yan Q,Li Y,Khan M,Ma T
Tue Sep 18 00:00:00 EDT 2018
Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.
Cell reports
Lin WC,Chakraborty A,Huang SC,Wang PY,Hsieh YJ,Chien KY,Lee YH,Chang CC,Tang HY,Lin YT,Tung CS,Luo JD,Chen TW,Lin TY,Cheng ML,Chen YT,Yeh CT,Liu JL,Sung LY,Shiao MS,Yu JS,Chang YS,Pai LM
Tue Sep 04 00:00:00 EDT 2018
Ticagrelor protects against AngII-induced endothelial dysfunction by alleviating endoplasmic reticulum stress.
Microvascular research
Wang X,Han X,Li M,Han Y,Zhang Y,Zhao S,Li Y
Sat Sep 01 00:00:00 EDT 2018
Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein.
JCI insight
Burman A,Kropski JA,Calvi CL,Serezani AP,Pascoalino BD,Han W,Sherrill T,Gleaves L,Lawson WE,Young LR,Blackwell TS,Tanjore H
Thu Aug 23 00:00:00 EDT 2018
Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.
Experimental cell research
Geng W,Qin F,Ren J,Xiao S,Wang A
Wed Aug 15 00:00:00 EDT 2018
TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.
Journal of molecular and cellular cardiology
Li Z,Meng Z,Lu J,Chen FM,Wong WT,Tse G,Zheng C,Keung W,Tse K,Li RA,Jiang L,Yao X
Sun Jul 01 00:00:00 EDT 2018
18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma.
Scientific reports
Chen J,Zhang ZQ,Song J,Liu QM,Wang C,Huang Z,Chu L,Liang HF,Zhang BX,Chen XP
Tue Jun 19 00:00:00 EDT 2018
eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer.
Cancer science
Tanaka I,Sato M,Kato T,Goto D,Kakumu T,Miyazawa A,Yogo N,Hase T,Morise M,Sekido Y,Girard L,Minna JD,Byers LA,Heymach JV,Coombes KR,Kondo M,Hasegawa Y
Fri Jun 01 00:00:00 EDT 2018
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Cell metabolism
Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC
Tue Apr 03 00:00:00 EDT 2018
Amino acid starvation-induced autophagy is involved in reduced subcutaneous fat deposition in weaning piglets derived from sows fed low-protein diet during gestation and lactation : Autophagy is involved in reduced fat deposition in maternal low-protein piglets.
European journal of nutrition
Pan S,Jia Y,Yang X,Cai D,Liu Z,Song H,Zhao R
Sun Apr 01 00:00:00 EDT 2018
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Marine drugs
Tsai TC,Lai KH,Su JH,Wu YJ,Sheu JH
Mon Mar 26 00:00:00 EDT 2018
Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.
Cell death & disease
Krishnamoorthy J,Tenkerian C,Gupta J,Ghaddar N,Wang S,Darini C,Staschke KA,Ghosh A,Gandin V,Topisirovic I,Kristof AS,Hatzoglou M,Simos G,Koromilas AE
Thu Feb 15 00:00:00 EST 2018
Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain.
Neuroscience
Beauvais G,Rodriguez-Losada N,Ying L,Zakirova Z,Watson JL,Readhead B,Gadue P,French DL,Ehrlich ME,Gonzalez-Alegre P
Sat Feb 10 00:00:00 EST 2018
Transthyretin Exerts Pro-Apoptotic Effects in Human Retinal Microvascular Endothelial Cells Through a GRP78-Dependent Pathway in Diabetic Retinopathy.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Shao J,Yin Y,Yin X,Ji L,Xin Y,Zou J,Yao Y
Tue Oct 31 00:00:00 EDT 2017
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
Free radical biology & medicine
Kim HJ,Joe Y,Kim SK,Park SU,Park J,Chen Y,Kim J,Ryu J,Cho GJ,Surh YJ,Ryter SW,Kim UH,Chung HT
Fri Sep 01 00:00:00 EDT 2017
β-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Liu Y,Jiang ZY,Zhou YL,Qiu HH,Wang G,Luo Y,Liu JB,Liu XW,Bu WQ,Song J,Cui L,Jia XB,Feng L
Fri Sep 01 00:00:00 EDT 2017
The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis.
Cancer biology & therapy
Wang G,Zhou P,Chen X,Zhao L,Tan J,Yang Y,Fang Y,Zhou J
Thu Aug 03 00:00:00 EDT 2017
Discovery of a Benzamide Derivative That Protects Pancreatic β-Cells against Endoplasmic Reticulum Stress.
Journal of medicinal chemistry
Duan H,Li Y,Arora D,Xu D,Lim HY,Wang W
Thu Jul 27 00:00:00 EDT 2017
A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure.
Nature communications
Yao Y,Lu Q,Hu Z,Yu Y,Chen Q,Wang QK
Tue Jul 25 00:00:00 EDT 2017
Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.
Scientific reports
Maryam A,Mehmood T,Zhang H,Li Y,Khan M,Ma T
Mon Jul 24 00:00:00 EDT 2017
DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.
Developmental cell
Nguyen TB,Louie SM,Daniele JR,Tran Q,Dillin A,Zoncu R,Nomura DK,Olzmann JA
Mon Jul 10 00:00:00 EDT 2017
Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR.
Cellular signalling
Yin Y,Chen C,Chen J,Zhan R,Zhang Q,Xu X,Li D,Li M
Sat Jul 01 00:00:00 EDT 2017
When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157.
Cell death and differentiation
Rojas-Rivera D,Delvaeye T,Roelandt R,Nerinckx W,Augustyns K,Vandenabeele P,Bertrand MJM
Thu Jun 01 00:00:00 EDT 2017
Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Xia HF,Zhu JY,Wang JN,Ren JG,Cai Y,Wang FQ,Zhang W,Chen G,Zhao YF,Zhao JH
Mon May 01 00:00:00 EDT 2017
Stress granules assembly affects detection of mRNA in living cells by the NanoFlares; an important aspect of the technology.
Biochimica et biophysica acta. General subjects
Wolczyk M,Podszywalow-Bartnicka P,Bugajski L,Piwocka K
Mon May 01 00:00:00 EDT 2017
AvidinOX-anchored biotinylated trastuzumab and pertuzumab induce down-modulation of ErbB2 and tumor cell death at concentrations order of magnitude lower than not-anchored antibodies.
Oncotarget
Milazzo FM,Anastasi AM,Chiapparino C,Rosi A,Leoni B,Vesci L,Petronzelli F,De Santis R
Tue Apr 04 00:00:00 EDT 2017
TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity.
Oxidative medicine and cellular longevity
Wang Y,Gu YH,Liu M,Bai Y,Liang LY,Wang HL
Mon Mar 27 00:00:00 EDT 2017
Knockdown of histidine-rich calcium-binding protein (HRC) suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells.
Biology open
Liu J,Li M,Gong J,Han P,Wang Y,Li D,Tian D,Liao J
Sun Jan 15 00:00:00 EST 2017
Endoplasmic reticulum stress and apoptosis via PERK-eIF2α-CHOP signaling in the methamphetamine-induced chronic pulmonary injury.
Environmental toxicology and pharmacology
Gu YH,Wang Y,Bai Y,Liu M,Wang HL
Sun Jan 01 00:00:00 EST 2017
Endoplasmic reticulum stress and apoptosis via PERK-eIF2α-CHOP signaling in the methamphetamine-induced chronic pulmonary injury.
Environmental toxicology and pharmacology
Gu YH,Wang Y,Bai Y,Liu M,Wang HL
Sun Jan 01 00:00:00 EST 2017
Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction.
International journal of molecular sciences
Lin JJ,Wang RY,Chen JC,Chiu CC,Liao MH,Wu YJ
Thu Oct 27 00:00:00 EDT 2016
Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Beauvais G,Bode NM,Watson JL,Wen H,Glenn KA,Kawano H,Harata NC,Ehrlich ME,Gonzalez-Alegre P
Wed Oct 05 00:00:00 EDT 2016
Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway.
Toxicology in vitro : an international journal published in association with BIBRA
Zhang W,Chen L,Shen Y,Xu J
Sat Oct 01 00:00:00 EDT 2016
Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway.
Toxicology in vitro : an international journal published in association with BIBRA
Zhang W,Chen L,Shen Y,Xu J
Sat Oct 01 00:00:00 EDT 2016
Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2α signaling pathway.
Brain, behavior, and immunity
Gao H,Yan P,Zhang S,Nie S,Huang F,Han H,Deng Q,Huang Q,Yang W,Wu H,Yao P,Ye K,Xu J,Liu L
Sat Oct 01 00:00:00 EDT 2016
EZH2 inhibitors transcriptionally upregulate cytotoxic autophagy and cytoprotective unfolded protein response in human colorectal cancer cells.
American journal of cancer research
Hsieh YY,Lo HL,Yang PM
Tue Sep 20 00:00:00 EDT 2016
Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress.
Journal of medicinal chemistry
Duan H,Lee JW,Moon SW,Arora D,Li Y,Lim HY,Wang W
Thu Sep 08 00:00:00 EDT 2016
N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells.
ACS chemical biology
Thinon E,Morales-Sanfrutos J,Mann DJ,Tate EW
Fri Aug 19 00:00:00 EDT 2016
The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress.
Oncotarget
Rajesh K,Krishnamoorthy J,Gupta J,Kazimierczak U,Papadakis AI,Deng Z,Wang S,Kuninaka S,Koromilas AE
Tue Aug 09 00:00:00 EDT 2016
Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta.
PLoS genetics
Cabral WA,Ishikawa M,Garten M,Makareeva EN,Sargent BM,Weis M,Barnes AM,Webb EA,Shaw NJ,Ala-Kokko L,Lacbawan FL,Högler W,Leikin S,Blank PS,Zimmerberg J,Eyre DR,Yamada Y,Marini JC
Fri Jul 01 00:00:00 EDT 2016
Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response.
Molecular and cellular biology
Reid DW,Tay AS,Sundaram JR,Lee IC,Chen Q,George SE,Nicchitta CV,Shenolikar S
Fri Jul 01 00:00:00 EDT 2016
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hu H,Wang C,Jin Y,Meng Q,Liu Q,Liu K,Sun H
Sun May 01 00:00:00 EDT 2016
Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells.
Cellular signalling
Moore JA,Miller WP,Dennis MD
Sun May 01 00:00:00 EDT 2016
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.
Nature communications
Krall AS,Xu S,Graeber TG,Braas D,Christofk HR
Fri Apr 29 00:00:00 EDT 2016
TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.
Journal of cellular biochemistry
Tsukumo Y,Tsukahara S,Furuno A,Iemura S,Natsume T,Tomida A
Mon Feb 01 00:00:00 EST 2016
Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice.
Biochemical and biophysical research communications
Fujita Y,Makishima M,Bhawal UK
Fri Jan 15 00:00:00 EST 2016
Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice.
Biochemical and biophysical research communications
Fujita Y,Makishima M,Bhawal UK
Fri Jan 15 00:00:00 EST 2016
mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress.
Molecular cancer research : MCR
Tenkerian C,Krishnamoorthy J,Mounir Z,Kazimierczak U,Khoutorsky A,Staschke KA,Kristof AS,Wang S,Hatzoglou M,Koromilas AE
Thu Oct 01 00:00:00 EDT 2015
Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation.
Cell cycle (Georgetown, Tex.)
Podszywalow-Bartnicka P,Wolczyk M,Kusio-Kobialka M,Wolanin K,Skowronek K,Nieborowska-Skorska M,Dasgupta Y,Skorski T,Piwocka K
Thu Sep 10 00:00:00 EDT 2015
The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells.
Cancer chemotherapy and pharmacology
Kraus J,Kraus M,Liu N,Besse L,Bader J,Geurink PP,de Bruin G,Kisselev AF,Overkleeft H,Driessen C
Sat Aug 01 00:00:00 EDT 2015
Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expression.
Bioorganic & medicinal chemistry
Duan H,Li Y,Lim HY,Wang W
Sat Aug 01 00:00:00 EDT 2015
TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.
PloS one
Tsukumo Y,Tsukahara S,Furuno A,Iemura S,Natsume T,Tomida A
Mon Jul 06 00:00:00 EDT 2015
Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.
Chemical research in toxicology
Xu D,Su C,Song X,Shi Q,Fu J,Hu L,Xia X,Song E,Song Y
Mon Jun 15 00:00:00 EDT 2015
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
Oncogene
Yang CS,Matsuura K,Huang NJ,Robeson AC,Huang B,Zhang L,Kornbluth S
Mon Jun 01 00:00:00 EDT 2015
STAMP2 increases oxidative stress and is critical for prostate cancer.
EMBO molecular medicine
Jin Y,Wang L,Qu S,Sheng X,Kristian A,Mælandsmo GM,Pällmann N,Yuca E,Tekedereli I,Gorgulu K,Alpay N,Sood A,Lopez-Berestein G,Fazli L,Rennie P,Risberg B,Wæhre H,Danielsen HE,Ozpolat B,Saatcioglu F
Sun Mar 01 00:00:00 EST 2015
Translation of 5' leaders is pervasive in genes resistant to eIF2 repression.
eLife
Andreev DE,O'Connor PB,Fahey C,Kenny EM,Terenin IM,Dmitriev SE,Cormican P,Morris DW,Shatsky IN,Baranov PV
Mon Jan 26 00:00:00 EST 2015
Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress.
Cell death & disease
Rajesh K,Krishnamoorthy J,Kazimierczak U,Tenkerian C,Papadakis AI,Wang S,Huang S,Koromilas AE
Thu Jan 15 00:00:00 EST 2015
PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.
Neurobiology of aging
Devi L,Ohno M
Wed Oct 01 00:00:00 EDT 2014
Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.
PloS one
Devi L,Ohno M
Tue Aug 05 00:00:00 EDT 2014
HKH40A downregulates GRP78/BiP expression in cancer cells.
Cell death & disease
Kosakowska-Cholody T,Lin J,Srideshikan SM,Scheffer L,Tarasova NI,Acharya JK
Thu May 22 00:00:00 EDT 2014
Ionizing radiation activates PERK/eIF2α/ATF4 signaling via ER stress-independent pathway in human vascular endothelial cells.
International journal of radiation biology
Kim EJ,Lee YJ,Kang S,Lim YB
Tue Apr 01 00:00:00 EDT 2014
Expression of ATF4 and VEGF in chorionic villus tissue in early spontaneous abortion.
European journal of obstetrics, gynecology, and reproductive biology
Chai L,Ling K,He X,Yang R
Tue Oct 01 00:00:00 EDT 2013
Sinulariolide induced hepatocellular carcinoma apoptosis through activation of mitochondrial-related apoptotic and PERK/eIF2α/ATF4/CHOP pathway.
Molecules (Basel, Switzerland)
Chen YJ,Su JH,Tsao CY,Hung CT,Chao HH,Lin JJ,Liao MH,Yang ZY,Huang HH,Tsai FJ,Weng SH,Wu YJ
Thu Aug 22 00:00:00 EDT 2013
Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling.
PloS one
Saito S,Furuno A,Sakurai J,Park HR,Shin-ya K,Tomida A
Thu Feb 28 00:00:00 EST 2013
Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipids.
Atherosclerosis
Afonyushkin T,Oskolkova OV,Bochkov VN
Thu Nov 01 00:00:00 EDT 2012
Proteomic profiling of the 11-dehydrosinulariolide-treated oral carcinoma cells Ca9-22: effects on the cell apoptosis through mitochondrial-related and ER stress pathway.
Journal of proteomics
Liu CI,Wang RY,Lin JJ,Su JH,Chiu CC,Chen JC,Chen JY,Wu YJ
Mon Oct 22 00:00:00 EDT 2012
Induction of apoptosis by 11-dehydrosinulariolide via mitochondrial dysregulation and ER stress pathways in human melanoma cells.
Marine drugs
Su TR,Tsai FJ,Lin JJ,Huang HH,Chiu CC,Su JH,Yang YT,Chen JY,Wong BS,Wu YJ
Wed Aug 01 00:00:00 EDT 2012
Role of ER stress response in photodynamic therapy: ROS generated in different subcellular compartments trigger diverse cell death pathways.
PloS one
Moserova I,Kralova J
Mon Jul 09 00:00:00 EDT 2012
Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells.
Oncology reports
Liang C,Li H,Zhou H,Zhang S,Liu Z,Zhou Q,Sun F
Sun Apr 01 00:00:00 EDT 2012
TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression.
Journal of neuroscience research
Suzuki H,Matsuoka M
Thu Mar 01 00:00:00 EST 2012
Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway.
Science signaling
Mounir Z,Krishnamoorthy JL,Wang S,Papadopoulou B,Campbell S,Muller WJ,Hatzoglou M,Koromilas AE
Tue Sep 27 00:00:00 EDT 2011
Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death.
Cell death and differentiation
Peidis P,Papadakis AI,Muaddi H,Richard S,Koromilas AE
Sat Jan 01 00:00:00 EST 2011
Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.
Molecular biology of the cell
Muaddi H,Majumder M,Peidis P,Papadakis AI,Holcik M,Scheuner D,Kaufman RJ,Hatzoglou M,Koromilas AE
Wed Sep 15 00:00:00 EDT 2010
Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress.
American journal of physiology. Renal physiology
Kawakami T,Inagi R,Wada T,Tanaka T,Fujita T,Nangaku M
Wed Sep 01 00:00:00 EDT 2010
eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jiang Z,Belforte JE,Lu Y,Yabe Y,Pickel J,Smith CB,Je HS,Lu B,Nakazawa K
Wed Feb 17 00:00:00 EST 2010
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.
The Journal of cell biology
Wang X,Rao RP,Kosakowska-Cholody T,Masood MA,Southon E,Zhang H,Berthet C,Nagashim K,Veenstra TK,Tessarollo L,Acharya U,Acharya JK
Mon Jan 12 00:00:00 EST 2009