Keep as concentrated solution.
Predicted reactivity: Mouse (85%), Rat (86%), Pig (82%), Sheep (82%), Rhesus Monkey (97%), Chimpanzee (98%), Bovine (81%).
Positive Control: HeLa, HeLa treated tunicamycin (4 µg/ml).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activating transcription factor 4; ATF 4; ATF4 protein; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB 2; CREB-2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; OTTHUMP00000199130; tax-re; tax-responsive enhancer element B67; Tax-responsive enhancer element-binding protein 67; TaxREB67
Gene Aliases: ATF4; CREB-2; CREB2; TAXREB67; TXREB
UniProt ID: (Human) P18848
Entrez Gene ID: (Human) 468
Molecular Function: DNA-binding transcription factor