Positive Control: human Atg10-transfected 293T
Predicted Reactivity: Mouse (80%), Bovine (84%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
ATG10 is involved in autophagy which is a process for the bulk degradation of cytosolic compartments by lysosomes/vacuoles. The formation of autophagosomes involves a dynamic rearrangement of the membrane for which two ubiquitin-like modifications (the conjugation of APG12p and the modification of a soluble form of MAP-LC3 to a membrane-bound form) are essential. APG10 is an E2-like enzyme involved in two ubiquitin-like modifications essential for autophagosome formation, ATG12 -ATG5 conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A), a homolog of yeast Apg8, to a membrane-bound form. The protein ATG10 is ubiquitously expressed and the human APG10L gene is localized on chromosome 5q14.2.
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Protein Aliases: APG10; APG10-like; APG10L; ATG10; ATG10 autophagy related 10 homolog; autophagy related 10; Autophagy-related protein 10; pp12616; Ubiquitin-like-conjugating enzyme ATG10
Gene Aliases: APG10; APG10L; ATG10; PP12616
UniProt ID: (Human) Q9H0Y0
Entrez Gene ID: (Human) 83734