Recommended positive controls: HeLa, HepG2, 293T, RD, mouse brain, rat brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ATG14 (Autophagy related protein homolog 14) is encoded by the ATG14 gene and is located on chromosome 14 in humans. It is also known as ATG14L or BARKOR (Beclin 1-associated autophagy-related key regulator). Autophagy is an evolutionarily conserved process that involves recycling of misfolded cellular proteins and degradation of dysfunctional organelles. Autophagy is induced as a cellular response to nutrient stress which includes the formation of autophagosomes, fusion of these with the lysosome and formation of the autophagolysosome. The Class III PI3-Kinase, Vps34 and its interacting partner Beclin 1 have been shown to form a complex which specifically includes ATG 14 (type 1) or UVRAG (type 2). Atg 14 guides the type 1 complex to the preautophagosomal structure (PAS) and is critical for the initiation of autophagosome formation.
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Protein Aliases: ATG14 autophagy related 14 homolog; Atg14-like protein; Atg14L; Autophagy-related protein 14-like protein; Bakor; Barkor; Beclin 1-associated autophagy-related key regulator; Beclin 1-Interacting protein; VATG14 autophagy related 14 homolog
Gene Aliases: 4832427M01; ATG14; ATG14L; BARKOR; D14Ertd114e; D14Ertd436e; KIAA0831; RGD1304610