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ATG16L1 Polyclonal Antibody
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FIGURE: 1 / 8
ATG16L1 Antibody (OSA00045W-150UL) in IHC (P)
IHC on rat spinal cord (paraffin section) using Rabbit antibody to autophagy-related protein 16-1 (ATG16L1, APG16L) isoforms 1, 2, 3: whole serum (OSA00045W) at 1 : 200 dilution incubated overnight at 4C, developed with DAB/No and counterstained with hematoxylin.
Product Details
OSA00045W-150UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from human ATG16L1 conjugated to blue carrier protein has been used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse and rat.
Specificity of this antibody: ATG16L1.
Target Information
Autophagy related protein 16 L is encoded by the ATG16L gene and is located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10). ATG 12 and ATG5 conjugate with each other and undergoes homo oligomerisation with ATG16L to form an 800 kDa complex called the Atg16L complex. This complex facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE) and this ubiquitin-like conjugation system is a widely used marker for autophagy. However, the ATG 16L complex along with other ATGs like ATG 18 and ATG 21 prevent the premature cleavage of ATG8-PE by the cysteine protease, Atg4 until the autophagosome is deemed complete.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A16L1; APG 16-L1; APG16-like 1; APG16L beta; APG16L isoforms 1; atg16; ATG16 autophagy related 16-like 1; ATG16L1; Autophagy-related protein 16-1; hCG_1817841; isoform 2 is encoded by transcript variant 2; unnamed protein product; WD repeat domain 30
Gene Aliases: APG16L; ATG16A; ATG16L; ATG16L1; IBD10; UNQ9393/PRO34307; WDR30
UniProt ID: (Human) Q676U5
Entrez Gene ID: (Human) 55054
autophagosome assembly
C-terminal protein lipidation
autophagy
positive regulation of autophagy
protein transport
macroautophagy
lysosomal microautophagy
hippocampus development
corpus callosum development
protein localization to pre-autophagosomal structure
negative stranded viral RNA replication
defense response to virus
xenophagy
axonal transport
dendrite arborization
negative regulation of dendrite extension
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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