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Proteintech
ATG3 Polyclonal Antibody
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Product Details
11262-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATG3 Fusion Protein Ag1785 (1-314 aa encoded by BC024221)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MQNVINTVK GKALEVAEYL TPVLKESKFK ETGVITPEEF VAAGDHLVHH CPTWQWATGE ELKVKAYLPT GKQFLVTKNV PCYKRCKQME YSDELEAIIE EDDGDGGWVD TYHNTGITGI TEAVKEITLE NKDNIRLQDC SALCEEEEDE DEGEAADMEE YEESGLLETD EATLDTRKIV EACKAKTDAG GEDAILQTRT YDLYITYDKY YQTPRLWLFG YDEQRQPLTV EHMYEDISQD HVKKTVTIEN HPHLPPPPMC SVHPCRHAEV MKKIIETVAE GGGELGVHMY LLIFLKFVQA VIPTIEYDYT RHFTM (1-314 aa encoded by BC024221)
Target Information
ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: APG3 autophagy 3-like; APG3-like; ATG3 autophagy related 3 homolog; autophagy-related 3; Autophagy-related protein 3; DKFZp564M1178; FLJ22125; MGC15201; Preconditioning-inducible gene 1 protein; Protein PC3-96; Ubiquitin-like-conjugating enzyme ATG3; unnamed protein product
Gene Aliases: 2610016C12Rik; APG3; APG3-LIKE; APG3L; ATG3; Atg3l; hApg3; PC3-96; PIG-1; Pig1
UniProt ID: (Human) Q9NT62, (Rat) Q6AZ50, (Mouse) Q9CPX6
Entrez Gene ID: (Human) 64422, (Rat) 171415, (Mouse) 67841
protein binding
transferase activity
Atg8 ligase activity
Atg12 transferase activity
ubiquitin-like protein transferase activity
enzyme binding
Atg8-family conjugating enzyme activity
molecular_function
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
autophagosome assembly
mitophagy
protein targeting to membrane
autophagy
protein transport
macroautophagy
protein ubiquitination
mitochondrial fragmentation involved in apoptotic process
nucleophagy
negative regulation of phagocytosis
glycophagy
regulation of cilium assembly
cellular protein modification process
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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