Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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It is not recommended to aliquot this antibody.
ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2610016C12Rik; APG3-like; Apg3p; ATG3 autophagy related 3 homolog; autophagy-related 3; Autophagy-related protein 3; DKFZp564M1178; FLJ22125; hApg3; MGC15201; Preconditioning-inducible gene 1 protein; Protein PC3-96; Ubiquitin-like-conjugating enzyme ATG3
Gene Aliases: 2610016C12Rik; APG3; APG3-LIKE; APG3L; ATG3; Atg3l; PC3-96; PIG-1; Pig1; XELAEV_18014721mg
UniProt ID: (Human) Q9NT62, (Bovine) Q0VCL3, (Rat) Q6AZ50, (Mouse) Q9CPX6, (Xenopus) Q6GQE7
Entrez Gene ID: (Human) 64422, (Bovine) 508571, (Chicken) 418369, (Dog) 478564, (Rat) 171415, (Mouse) 67841, (Xenopus) 443885
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