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Invitrogen
ATG4A Polyclonal Antibody
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FIGURE: 1 / 3
ATG4A Antibody (PA5-116489) in IHC (P)
Immunohistochemical analysis of ATG4A in a paraffin-embedded human placenta tissue using a ATG4A polyclonal antibody (Product #PA5-116489). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:50) for 30... View More
Product Details
PA5-116489
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within Human ATG4A aa 87-314.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive controls: Human placenta tissue, mouse testis tissue, rat bone marrow.
Target Information
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APG4 (ATG4) autophagy-related homolog A; APG4 autophagy 4 homolog A; ATG4 autophagy related 4 homolog A; AUT-like 2 cysteine endopeptidase; AUT-like 2, cysteine endopeptidase; autophagin 2; Autophagin-2; autophagy 4 homolog A; autophagy related 4 homolog A; autophagy related 4A, cysteine peptidase; autophagy-related 4A; Autophagy-related cysteine endopeptidase 2; Autophagy-related protein 4 homolog A; cysteine protease APG4A; Cysteine protease ATG4A; hAPG4A; HsAPG4A; MGC107179; unnamed protein product
Gene Aliases: AI627006; APG4A; ATG4A; Atg4al; AUTL2; AV169859; HsAPG4A
UniProt ID: (Human) Q8WYN0, (Mouse) Q8C9S8
Entrez Gene ID: (Human) 115201, (Mouse) 666468, (Rat) 678769
autophagosome assembly
mitophagy
proteolysis
lipid metabolic process
autophagy
protein transport
protein processing
piecemeal microautophagy of nucleus
aggrephagy
protein delipidation
mitophagy
C-terminal protein lipidation
protein targeting to membrane
cellular response to nitrogen starvation
nucleophagy
biological_process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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