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Proteintech
ATG4B Polyclonal Antibody
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Product Details
15131-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATG4B Fusion Protein Ag7261 (1-393 aa encoded by BC000719)
Conjugate
Form
Liquid
Concentration
0.54 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDAATLTYD TLRFAEFEDF PETSEPVWIL GRKYSIFTEK DEILSDVASR LWFTYRKNFP AIGGTGPTSD TGWGCMLRCG QMIFAQALVC RHLGRDWRWT QRKRQPDSYF SVLNAFIDRK DSYYSIHQIA QMGVGEGKSI GQWYGPNTVA QVLKKLAVFD TWSSLAVHIA MDNTVVMEEI RRLCRTSVPC AGATAFPADS DRHCNGFPAG AEVTNRPSPW RPLVLLIPLR LGLTDINEAY VETLKHCFMM PQSLGVIGGK PNSAHYFIGY VGEELIYLDP HTTQPAVEPT DGCFIPDESF HCQHPPCRMS IAELDPSIAV GFFCKTEDDF NDWCQQVKKL SLLGGALPMF ELVEQQPSHL ACPDVLNLSL DSSDVERLER FFDSEDEDFE ILSL (1-393 aa encoded by BC000719)
Target Information
Cysteine protease ATG4b is an enzyme which is coded by ATG4b gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4b is a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4b, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4b is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: APG4 (ATG4) autophagy-related homolog B; APG4 autophagy 4 homolog B; ATG4 autophagy related 4 homolog B; AUT-like 1 cysteine; AUT-like 1 cysteine endopeptidase; AUT-like 1, cysteine endopeptidase; autophagin 1; Autophagin-1; autophagy related 4 homolog B; autophagy related 4B, cysteine peptidase; autophagy-related 4B; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; Cysteine protease ATG4B; cysteine protease involved in autophagy APG4-B; hAPG4B; HsAPG4B; MmAPG4B
Gene Aliases: 2510009N07Rik; APG4B; ATG4B; Atg4bl; AUTL1; AW048066; KIAA0943
UniProt ID: (Human) Q9Y4P1, (Mouse) Q8BGE6
Entrez Gene ID: (Human) 23192, (Mouse) 66615, (Rat) 316640
autophagosome assembly
mitophagy
C-terminal protein lipidation
proteolysis
protein targeting to membrane
autophagy
macroautophagy
protein processing
nucleophagy
positive regulation of protein catabolic process
protein delipidation
transport
cellular response to nitrogen starvation
positive regulation of autophagy
protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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