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Proteintech
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Immunogen sequence: MAKNRRDRN SWGGFSEKTY EWSSEEEEPV KKAGPVQVLI VKDEHSFELD ETALNRILLS EAVRDKEVVA VSVAGAFRKG KSFLMDFMLR YMYNQESVDW VGDYNEPLTG FSWRGGSERE TTGIQIWSEI FLINKPDGKK VAVLLMDTQG TFDSQSTLRD SATVFALSTM ISSIQVYNLS QNVQEDDLQH LQLCTEYGRL AMEETFLKPF QSLIFLVRDW SFPYEFSYGA DGGAKFLEKR LKVSGNQHEE LQNVRKHIHS CFTNISCFLL PHPGLKVATN PNFDGKLKEI DDEFIKNLKI LIPWLLSPES LDIKEINGNK ITCRGLVEYF KAYIKIYQGE ELPHPKSMLQ A (1-350 aa encoded by BC010708)
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
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