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Invitrogen
ATOH1 Polyclonal Antibody
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FIGURE: 1 / 1
ATOH1 Antibody (PA5-97480) in WB
Western Blot analysis of MATH1 using a MATH1 Polyclonal antibody (Product # PA5-97480) at a concentration of 3.4 µg/mL. Positive WB detected in: Mouse kidney tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 38 kDa.
Product Details
PA5-97480
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Mouse Protein atonal homolog 1 protein (1-351AA)
Conjugate
Form
Liquid
Concentration
5 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9. 5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Atonal bHLH transcription factor 1; H MATH-1; Helix-loop-helix protein mATH-1; mATH1; Protein atonal homolog 1; Transcription factor Atoh1
Gene Aliases: Ath1; Atoh1; bHLHa14; Hath1; MATH-1; Math1
UniProt ID: (Mouse) P48985
Entrez Gene ID: (Mouse) 11921
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
protein binding
chromatin DNA binding
sequence-specific DNA binding
protein dimerization activity
basic helix-loop-helix transcription factor
neuron migration
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
multicellular organism development
nervous system development
axon guidance
brain development
cerebral cortex development
cell differentiation
neuron differentiation
inner ear morphogenesis
auditory receptor cell differentiation
auditory receptor cell fate specification
auditory receptor cell fate determination
negative regulation of apoptotic process
positive regulation of auditory receptor cell differentiation
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
inner ear development
positive regulation of inner ear receptor cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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