This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-29495 targets ATP citrate lyase in IF and WB applications and shows reactivity with Human, Rat and mouse samples.
The PA5-29495 immunogen is recombinant fragment corresponding to a region within amino acids 743 and 1038 of Human ATP citrate lyase.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
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Protein Aliases: ACL; ATP citrate synthase; ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; ATPCL; Citrate cleavage enzyme; CLATP
Gene Aliases: A730098H14Rik; ACL; ACLY; ATPCL; AW538652; CLATP