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Invitrogen
ATP11A Polyclonal Antibody
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Product Details
PA5-20995
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 19 amino acid peptide near the amino terminus of human ATP11A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is K562 cell lysate.
PA5-20995 can be used with blocking peptide PEP-1109.
Target Information
ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase 11A, class VI; ATPase 11A, p type; ATPase class VI type 11A; ATPase IS; ATPase, class 1, member h; ATPase, class VI, type 11A; P4-ATPase flippase complex alpha subunit ATP11A; phospholipid-translocating ATPase; Phospholipid-transporting ATPase IH; potential phospholipid-transporting ATPase IH; probable phospholipid-transporting ATPase IH; RP11-120K24.1; unnamed protein product
Gene Aliases: 4930558F19Rik; ATP11A; Atpc1h; ATPIH; ATPIS; AU040868; AUNA2; DFNA84; HLD24; Ih; KIAA1021; Ua20
UniProt ID: (Human) P98196, (Mouse) P98197
Entrez Gene ID: (Human) 23250, (Mouse) 50770, (Rat) 306600
nucleotide binding
magnesium ion binding
protein binding
ATP binding
ATPase activity
metal ion binding
phosphatidylethanolamine flippase activity
phosphatidylserine-translocating ATPase activity
ATPase-coupled intramembrane lipid transporter activity
phosphatidylserine flippase activity
phospholipid-translocating ATPase activity
hydrolase activity
primary active transporter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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