Immunogen sequence: SATGEIYLFC KGADSSIFPR VIEGKVDQIR ARVERNAVEG LRTLCVAYKR LIQEEYEGIC KLLQAAKVAL QDREKKLAEA YEQIEKDLTL LG
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.
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Protein Aliases: ATPase class VI type 11A; ATPase IS; ATPase, class VI, type 11A; P4-ATPase flippase complex alpha subunit ATP11A; phospholipid-translocating ATPase; potential phospholipid-transporting ATPase IH; Probable phospholipid-transporting ATPase IH; RP11-120K24.1, ATPIH, ATPIS
Gene Aliases: ATP11A; ATPIH; ATPIS; KIAA1021
UniProt ID: (Human) P98196
Entrez Gene ID: (Human) 23250