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Immunogen sequence: MKYQEINGRL VPEGPTPDSS EGNLSYLSSL SHLNNLSHLT TSSSFRTSPE NETELIKEHD LFFKAVSLCH TVQISNVQTD CTGDGPWQSN LAPSQLEY
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 80%.
ATP11B is a widely expressed integral membrane ATPase and is thought to drive the transport of phospholipids across membranes. It has been suggested that ATP11B is hormonally regulated and plays a role in the subnuclear trafficking of transcription factors with RING motifs. While the exact molecule ATP11B transports is unknown, increased mRNA expression of the homologous ATP11A has been observed in cells resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs), suggesting that ATP11B may also play a role in cell survival under harsh conditions.
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Protein Aliases: ATPase class VI type 11B; ATPase IR; ATPase, class VI, type 11B; P4-ATPase flippase complex alpha subunit ATP11B; Phospholipid-transporting ATPase IF; TIEG; TIEG1; truncated ATPase 11B protein
Gene Aliases: ATP11B; ATPIF; ATPIR; KIAA0956
UniProt ID: (Human) Q9Y2G3
Entrez Gene ID: (Human) 23200
Molecular Function: primary active transporter