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Suggested positive control: human and mouse brain membrane prep lysate.
Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders. ATP13A2, otherwise known as PARK9, is a neuronal P-type ATPase gene underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia. ATP13A2 protein is located in the membrane of these lysosomes and is formed most strongly in the brain, especially in the substantia nigra, a brain region which is known to play a central role in Parkinson's disease.
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Protein Aliases: AT132 antibody; ATPase type 13A2; Cation-transporting ATPase 13A2; HSA9947 antibody; probable cation-transporting ATPase 13A2; putative ATPase; RP1-37C10.4
Gene Aliases: 1110012E06Rik; AA589443; ATP13A2; CLN12; HSA9947; KRPPD; PARK9
UniProt ID: (Human) Q9NQ11, (Mouse) Q9CTG6
Entrez Gene ID: (Human) 23400, (Mouse) 74772
Molecular Function:
cation transporter
hydrolase
ion channel
transporter
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