Invitrogen

ATP13A2 Polyclonal Antibody

View all (8) ATP13A2 antibodies

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Questions & Answers

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ATP13A2 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of neurons and neuropils using a concentration of 10 µg/mL. Human brain, 40X.

ATP13A2 Antibody in Western Blot (WB) — Western Blot detection of ATP13A2 in mouse brain membrane lysate.

Product Details

Tested Applications

Dilution

Immunohistochemistry (IHC)

10 µg/mL

Western Blot (WB)

2 µg/mL

Product Specifications

Species Reactivity

Human, Mouse

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues 200-300 of human ATP13A2.

Conjugate

Unconjugated

Form

Liquid

Concentration

0.75 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

tris glycine with 150mM NaCl

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2063283

Product Specific Information

Suggested positive control: human and mouse brain membrane prep lysate.

Target Information

Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders. ATP13A2 is a neuronal P-type ATPase gene underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia. ATP13A2 protein is located in the membrane of these lysosomes and is formed most strongly in the brain, especially in the substantia nigra, a brain region which is known to play a central role in Parkinson's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: AT132 antibody; ATPase type 13A2; Cation-transporting ATPase 13A2; HSA9947 antibody; probable cation-transporting ATPase 13A2

Gene Aliases: 1110012E06Rik; AA589443; ATP13A2; CLN12; HSA9947; KRPPD; PARK9

UniProt ID: (Human) Q9NQ11, (Mouse) Q9CTG6

Entrez Gene ID: (Human) 23400, (Mouse) 74772

Molecular Function: cation transporter hydrolase ion channel transporter

cellular calcium ion homeostasis cellular iron ion homeostasis cellular zinc ion homeostasis regulation of mitochondrion organization regulation of macroautophagy regulation of autophagosome size cellular cation homeostasis regulation of intracellular protein transport ion transmembrane transport cellular response to oxidative stress protein autophosphorylation positive regulation of protein secretion regulation of endopeptidase activity zinc ion homeostasis cellular response to manganese ion cellular response to zinc ion cation transmembrane transport negative regulation of neuron death regulation of mitophagy positive regulation of exosomal secretion regulation of chaperone-mediated autophagy autophagosome organization polyamine import regulation of lysosomal protein catabolic process negative regulation of lysosomal protein catabolic process peptidyl-aspartic acid autophosphorylation cation transport

Process(es)

protein binding ATP binding zinc ion binding ATPase activity cation-transporting ATPase activity manganese ion binding phosphatidic acid binding phosphatidylinositol-3,5-bisphosphate binding cupric ion binding nucleotide binding hydrolase activity metal ion binding