Sequence of this protein is as follows: WKPLWGVRLR LRPCNLAHAE TLVIEIRDKE DSSWQLFTVQ VQTEAIGEGS LEPSPQSQAE DGRSQAAVGA VPEGAWKDTA QLHKSEEAKR VLRYYLFQGQ RYIWIETQQA FYQVSLLDHG RSCDDVHRSR HGLSLQDQMV RKAI
Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders. ATP13A2, otherwise known as PARK9, is a neuronal P-type ATPase gene underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia. ATP13A2 protein is located in the membrane of these lysosomes and is formed most strongly in the brain, especially in the substantia nigra, a brain region which is known to play a central role in Parkinson's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AT132 antibody; ATPase type 13A2; HSA9947 antibody; Polyamine-transporting ATPase 13A2; probable cation-transporting ATPase 13A2; putative ATPase; RP1-37C10.4
Gene Aliases: 1110012E06Rik; AA589443; ATP13A2; CLN12; HSA9947; KRPPD; PARK9; RGD1307977