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Invitrogen
ATP13A2 Polyclonal Antibody, HRP
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Product Details
PA5-22852
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to an internal region of the human ATP13A2 protein (within residues 200-300).
Conjugate
Form
Liquid
Concentration
0.75 mg/mL
Amount
75 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: human and mouse brain membrane prep lysate.
Target Information
Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders. ATP13A2, otherwise known as PARK9, is a neuronal P-type ATPase gene underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia. ATP13A2 protein is located in the membrane of these lysosomes and is formed most strongly in the brain, especially in the substantia nigra, a brain region which is known to play a central role in Parkinson's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AT132 antibody; ATPase 13A2; ATPase type 13A2; cation-transporting ATPase 13A2; HSA9947 antibody; Polyamine-transporting ATPase 13A2; probable cation-transporting ATPase 13A2; putative ATPase; RP1-37C10.4; unnamed protein product
Gene Aliases: 1110012E06Rik; AA589443; ATP13A2; CLN12; HSA9947; KRPPD; PARK9; SPG78
UniProt ID: (Human) Q9NQ11, (Mouse) Q9CTG6
Entrez Gene ID: (Human) 23400, (Mouse) 74772
nucleotide binding
protein binding
ATP binding
zinc ion binding
lipid binding
polyamine transmembrane transporter activity
polyamine-transporting ATPase activity
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
ATPase activity
cation-transporting ATPase activity
manganese ion binding
metal ion binding
phosphatidic acid binding
phosphatidylinositol-3,5-bisphosphate binding
P-type transmembrane transporter activity
cupric ion binding
hydrolase activity
cellular calcium ion homeostasis
cellular iron ion homeostasis
cellular zinc ion homeostasis
autophagy
lysosomal transport
positive regulation of gene expression
regulation of mitochondrion organization
regulation of macroautophagy
regulation of autophagosome size
cellular cation homeostasis
regulation of intracellular protein transport
ion transmembrane transport
cellular response to oxidative stress
regulation of neuron apoptotic process
positive regulation of protein secretion
lipid homeostasis
protein localization to lysosome
autophagosome-lysosome fusion
cellular response to manganese ion
cellular response to zinc ion
extracellular exosome biogenesis
cation transmembrane transport
regulation of protein localization to nucleus
polyamine transmembrane transport
regulation of mitophagy
positive regulation of exosomal secretion
spermine transmembrane transport
regulation of chaperone-mediated autophagy
autophagosome organization
regulation of lysosomal protein catabolic process
negative regulation of lysosomal protein catabolic process
cation transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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