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ATP1A2/ATP1A3 Polyclonal Antibody
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Product Details
OSA00277W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 970-1013 of human ATP1A3 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse and shares 95% identity with rat and mouse ATP1A2 sequences.
Specificity of this antibody: ATP1A3 and ATP1A2.
Target Information
The protein encoded by these genes belong to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes [provided by RefSeq, Oct 2008]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 3 polypeptide; ATPase, Na+K+ transporting, alpha 2; ATPase, Na+K+ transporting, alpha 3 subunit; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+, K+ activated adenosine triphosphatase alpha subunit; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ -ATPase alpha 3 subunit; Na+/K+ ATPase 3; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Na,K-ATPase subunit alpha-B; Sodium pump subunit alpha-2; Sodium pump subunit alpha-3; sodium-potassium ATPase catalytic subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-3; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-2 chain; sodium/potassium-transporting ATPase alpha-3 chain; Sodium/potassium-transporting ATPase subunit alpha-2; Sodium/potassium-transporting ATPase subunit alpha-3; unnamed protein product
Gene Aliases: AHC2; ATP1A1; ATP1A2; ATP1A3; Atpa-2; Atpa-3; Atpa1a3; AW060654; CAPOS; DEE98; DEE99; DYT12; FARIMPD; FHM2; KIAA0778; MHP2; mKIAA0778; RATATPA2; RDP
UniProt ID: (Human) P50993, (Human) P13637, (Rat) P06686, (Mouse) Q6PIE5, (Rat) P06687, (Mouse) Q6PIC6
Entrez Gene ID: (Human) 477, (Human) 478, (Rat) 24212, (Mouse) 98660, (Rat) 24213, (Mouse) 232975
nucleotide binding
sodium:potassium-exchanging ATPase activity
steroid binding
protein binding
ATP binding
potassium-transporting ATPase activity
phosphatase activity
ATPase activity
cation-transporting ATPase activity
potassium ion binding
sodium ion binding
metal ion binding
protein heterodimerization activity
chaperone binding
steroid hormone binding
beta-amyloid binding
hydrolase activity
D1 dopamine receptor binding
heparan sulfate proteoglycan binding
sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
primary active transporter
neurotransmitter uptake
behavioral fear response
regulation of the force of heart contraction
regulation of respiratory gaseous exchange by neurological system process
ion transport
potassium ion transport
sodium ion transport
cellular sodium ion homeostasis
regulation of muscle contraction
regulation of smooth muscle contraction
regulation of striated muscle contraction
cell communication
blood circulation
regulation of heart contraction
regulation of blood pressure
adult locomotory behavior
visual learning
establishment or maintenance of transmembrane electrochemical gradient
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
response to auditory stimulus
neuronal action potential propagation
regulation of vasoconstriction
L-ascorbic acid metabolic process
amygdala development
olfactory cortex development
cellular cation homeostasis
cellular potassium ion homeostasis
response to nicotine
locomotory exploration behavior
sodium ion transmembrane transport
response to potassium ion
sodium ion export from cell
locomotion
fear response
negative regulation of heart contraction
positive regulation of heart contraction
negative regulation of striated muscle contraction
ATP metabolic process
negative regulation of cytosolic calcium ion concentration
membrane depolarization
regulation of glutamate uptake involved in transmission of nerve impulse
regulation of synaptic transmission, glutamatergic
relaxation of cardiac muscle
cardiac muscle contraction
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
potassium ion transmembrane transport
regulation of cardiac muscle cell contraction
membrane repolarization
membrane depolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
cation transmembrane transport
transport across blood-brain barrier
hydrogen ion transmembrane transport
negative regulation of calcium ion transmembrane transport
response to glycoside
potassium ion import across plasma membrane
regulation of resting membrane potential
cellular response to beta-amyloid
neuron projection maintenance
metabolic process
potassium ion import
regulation of cardiac muscle contraction by calcium ion signaling
energy coupled proton transmembrane transport, against electrochemical gradient
ATP hydrolysis coupled proton transport
negative regulation of calcium:sodium antiporter activity
transport
memory
ionotropic glutamate receptor signaling pathway
response to drug
regulation of cardiac muscle cell membrane potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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