Invitrogen

ATP1A2 Polyclonal Antibody

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ATP1A2 Polyclonal Antibody

Product Details

PA5-101902

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ATP1A2(Accession P50993), corresponding to amino acid residues R3-Y53.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2851334

Product Specific Information

Antibody detects endogenous levels of total ATP1A2.

Target Information

Atp1a2 encodes an Na+/K+ ATPase, which is a membrane protein that is composed of two subunits - alpha and beta. The Na+/K+ ATPase pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions. The Atp1a2 encoded protein belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These ion gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. The ATPase enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta), and the catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. The Atp1a2 gene encodes an alpha 2 subunit. Mutations in the Atp1a2 gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. Diseases associated with ATP1A2 include Alternating Hemiplegia Of Childhood and Migraine, Familial Hemiplegic, 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Sodium Potassium ATPase; Sodium pump subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-2; sodium/potassium-transporting ATPase alpha-2 chain; Sodium/potassium-transporting ATPase subunit alpha-2

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Gene Aliases: ATP1A2; Atpa-3; AW060654; FHM2; KIAA0778; MHP2; mKIAA0778; RATATPA2

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UniProt ID: (Human) P50993, (Rat) P06686, (Mouse) Q6PIE5

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Entrez Gene ID: (Human) 477, (Rat) 24212, (Mouse) 98660

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Function(s)
sodium:potassium-exchanging ATPase activity protein binding ATP binding drug binding ATPase activity potassium ion binding sodium ion binding chaperone binding steroid hormone binding cation-transporting ATPase activity metal ion binding nucleotide binding hydrolase activity primary active transporter
Process(es)
neurotransmitter uptake regulation of the force of heart contraction regulation of respiratory gaseous exchange by neurological system process potassium ion transport sodium ion transport cellular sodium ion homeostasis regulation of smooth muscle contraction regulation of striated muscle contraction regulation of blood pressure adult locomotory behavior visual learning potassium ion import establishment or maintenance of transmembrane electrochemical gradient regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ATP hydrolysis coupled proton transport regulation of vasoconstriction cellular potassium ion homeostasis ion transmembrane transport response to nicotine sodium ion export from cell locomotion negative regulation of heart contraction negative regulation of striated muscle contraction ATP metabolic process negative regulation of cytosolic calcium ion concentration regulation of glutamate uptake involved in transmission of nerve impulse regulation of synaptic transmission, glutamatergic relaxation of cardiac muscle cardiac muscle contraction cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction membrane repolarization membrane depolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction negative regulation of calcium ion transmembrane transport negative regulation of calcium:sodium antiporter activity response to glycoside regulation of cardiac conduction potassium ion import across plasma membrane regulation of muscle contraction metabolic process regulation of cardiac muscle contraction by calcium ion signaling energy coupled proton transmembrane transport, against electrochemical gradient transport ion transport
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