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Proteintech
ATP1A3 (middle) Polyclonal Antibody
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Product Details
28030-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATP1A3 (middle) Fusion Protein Ag27705 (378-580 aa encoded by BC015566)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is generated against the middle region (378-580aa) of ATP1A3 and detects 113 kDa protein in SDS-PAGE.
Immunogen sequence: VAHMWFDNQ IHEADTTEDQ SGTSFDKSSH TWVALSHIAG LCNRAVFKGG QDNIPVLKRD VAGDASESAL LKCIELSSGS VKLMRERNKK VAEIPFNSTN KYQLSIHETE DPNDNRYLLV MKGAPERILD RCSTILLQGK EQPLDEEMKE AFQNAYLELG GLGERVLGFC HYYLPEEQFP KGFAFDCDDV NFTTDNLCFV GLMS (378-580 aa encoded by BC015566)
Target Information
The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase, Na+/K+ transporting, alpha 3 polypeptide; EC 3.6.3.9; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+, K+ activated adenosine triphosphatase alpha subunit; Na+/K+ ATPase 3; Sodium Potassium ATPase; Sodium pump 3; Sodium pump subunit alpha-3; sodium-potassium ATPase catalytic subunit alpha-3; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-3 chain; Sodium/potassium-transporting ATPase subunit alpha-3; unnamed protein product
Gene Aliases: AHC2; ATP1A1; ATP1A3; CAPOS; DEE99; DYT12; RDP
UniProt ID: (Human) P13637
Entrez Gene ID: (Human) 478
ion transport
potassium ion transport
sodium ion transport
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
cellular cation homeostasis
cellular potassium ion homeostasis
sodium ion export from cell
regulation of resting membrane potential
cellular response to steroid hormone stimulus
cell communication by electrical coupling involved in cardiac conduction
hydrogen ion transmembrane transport
response to glycoside
cellular response to beta-amyloid
neuron projection maintenance
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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