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Invitrogen
ATP1B1 Polyclonal Antibody
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FIGURE: 1 / 4
ATP1B1 Antibody (PA5-96428) in IHC (P)
Immunohistochemistry analysis of ATP1B1 in paraffin-embedded human colon carcinoma. Samples were incubated with ATP1B1 Polyclonal antibody (Product # PA5-96428) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-96428
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 63-303 of human ATP1B1 (NP_0016681)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Amount
53 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EFKPTYQDRV APPGLTQIPQ IQKTEISFRP NDPKSYEAYV LNIVRFLEKY KDSAQRDDMI FEDCGDVPSE PKERGDFNHE RGERKVCRFK LEWLGNCSGL NDETYGYKEG KPCIIIKLNR VLGFKPKPPK NESLETYPVM KYNPNVLPVQ CTGKRDEDKD KVGNVEYFGL GNSPGFPLQY YPYYGKLLQP KYLQPLLAVQ FTNLTMDTEI RIECKAYGEN IGYSEKDRFQ GRFDVKIEVK S; Positive Samples: HepG2, A-549, U-251MG; Cellular Location: Cell membrane, Single-pass type II membrane protein
Target Information
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenosinetriphosphatase; ATP1B1; ATPase, Na+/K+ transporting, beta 1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; MGC1798; Na+/K+ ATPase Beta; Na, K-ATPase beta-1 polypeptide; OTTHUMP00000032537; OTTHUMP00000032538; Sodium Potassium ATPase; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium ATPase beta subunit; sodium/potassium-dependent ATPase beta-1 subunit; Sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase beta-1 chain; Sodium/potassium-transporting ATPase subunit beta-1; unnamed protein product
Gene Aliases: ATP1B; ATP1B1; Atp4b; Atpb; Atpb-1; NKbeta1
UniProt ID: (Human) P05026, (Mouse) P14094
Entrez Gene ID: (Human) 481, (Mouse) 11931
ATPase activator activity
sodium:potassium-exchanging ATPase activity
protein binding
protein kinase binding
MHC class II protein complex binding
protein binding, bridging
protein heterodimerization activity
ATPase binding
transporter activator activity
protein C-terminus binding
primary active transporter
response to hypoxia
immune system process
ion transport
potassium ion transport
sodium ion transport
cellular calcium ion homeostasis
cellular sodium ion homeostasis
cell adhesion
establishment or maintenance of transmembrane electrochemical gradient
regulation of gene expression
regulation of cardiac muscle contraction by calcium ion signaling
metal ion transport
cellular potassium ion homeostasis
sodium ion transmembrane transport
sodium ion export from cell
protein transport into plasma membrane raft
innate immune response
ATP metabolic process
protein stabilization
relaxation of cardiac muscle
cardiac muscle contraction
protein localization to plasma membrane
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
hydrogen ion transmembrane transport
regulation of calcium ion transmembrane transport
positive regulation of sodium ion export from cell
positive regulation of potassium ion import
potassium ion import across plasma membrane
blastocyst development
positive regulation of defense response to virus by host
transport
potassium ion import
positive regulation of ATPase activity
mitophagy in response to mitochondrial depolarization
positive regulation of potassium ion transmembrane transporter activity
positive regulation of calcium:sodium antiporter activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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