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Proteintech
ATP2B1 Polyclonal Antibody
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Product Details
30035-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATP2B1 fusion protein Ag32423
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: GDMANNSVAY SGVKNSLKEA NHDGDFGITL AELRALMELR STDALRKIQE SYGDVYGICT KLKTSPNEGL SGNPADLERR EAVFGKNF
Target Information
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/potassium pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase, Ca++ transporting, plasma membrane 1; calcium pump; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 1; plasma membrane calcium pump; Plasma membrane calcium pump isoform 1; plasma membrane calcium-ATPase isoform 1 alternative splice variant k at splice site B and splice variant b at splice site C; Plasma membrane calcium-transporting ATPase 1; PMCA1
Gene Aliases: 2810442I22Rik; ATP2B1; E130111D10Rik; MRD66; PMCA1; PMCA1kb
UniProt ID: (Human) P20020, (Mouse) G5E829
Entrez Gene ID: (Human) 490, (Mouse) 67972
negative regulation of cytokine production
regulation of vascular smooth muscle contraction
ion transport
calcium ion transport
cellular calcium ion homeostasis
regulation of blood pressure
positive regulation of bone mineralization
ion transmembrane transport
regulation of cytosolic calcium ion concentration
negative regulation of cytosolic calcium ion concentration
positive regulation of calcium ion transport
calcium ion transmembrane transport
regulation of cellular response to insulin stimulus
regulation of cardiac conduction
calcium ion export from cell
transport
calcium ion export
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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