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Proteintech
ATP2C1 Polyclonal Antibody
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Product Details
13310-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATP2C1 Fusion Protein Ag4143 (320-654 aa encoded by BC028139)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LGVMRMVKK RAIVKKLPIV ETLGCCNVIC SDKTGTLTKN EMTVTHIFTS DGLHAEVTGV GYNQFGEVIV DGDVVHGFYN PAVSRIVEAG CVCNDAVIRN NTLMGKPTEG ALIALAMKMG LDGLQQDYIR KAEYPFSSEQ KWMAVKCVHR TQQDRPEICF MKGAYEQVIK YCTTYQSKGQ TLTLTQQQRD VYQQEKARMG SAGLRVLALA SGPELGQLTF LGLVGIIDPP RTGVKEAVTT LIASGVSIKM ITGDSQETAV AIASRLGLYS KTSQSVSGEE IDAMDVQQLS QIVPKVAVFY RASPRHKMKI IKSLQKNGSV VAMTGDGVND AVALKA (320-654 aa encoded by BC028139)
Target Information
ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; ATPase, Ca(2+)-sequestering; ATPase, Ca++ transporting, type 2C, member 1; ATPase, Ca++-sequestering; Ca(2+)/Mn(2+)-ATPase 2C1; calcium-transporting ATPase 2C1; Calcium-transporting ATPase type 2C member 1; HUSSY 28; HUSSY-28; rat; secretory pathway Ca(2+)-ATPase 1; Secretory pathway Ca(2+)-transporting ATPase type 1; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA1
Gene Aliases: 1700121J11Rik; ATP2C1; ATP2C1A; AW061228; BCPM; D930003G21Rik; HHD; hSPCA1; HUSSY-28; KIAA1347; PMR1; PMR1L; SPCA; SPCA1
UniProt ID: (Human) P98194, (Mouse) Q80XR2
Entrez Gene ID: (Human) 27032, (Rat) 170699, (Mouse) 235574
calcium ion transport
cellular calcium ion homeostasis
signal transduction
epidermis development
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
actin cytoskeleton reorganization
Golgi calcium ion homeostasis
Golgi calcium ion transport
ion transmembrane transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
calcium ion transmembrane transport
manganese ion transport
metabolic process
cellular manganese ion homeostasis
calcium ion import
manganese ion transmembrane transport
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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