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| Applications | Tested Dilution | Publications |
|---|---|---|
Immunocytochemistry (ICC/IF) |
0.25-2 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant Human ATP2C2 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.05 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2662202 |
Immunogen sequence: WMAVKCSLKTE DQEDIYFMKG ALEEVIRYCT MYNNGGIPLP LTPQQRSFCL QEEKRM
Highest antigen sequence identity to the following orthologs - mouse 77%, rat 77%.
ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATPase 2C2; ATPase, Ca++ transporting, type 2C, member 2; Calcium-transporting ATPase type 2C member 2; Secretory pathway Ca(2+)-ATPase 2; secretory pathway calcium ATPase 2
Gene Aliases: ATP2C2; KIAA0703; SPCA2
UniProt ID: (Human) O75185
Entrez Gene ID: (Human) 9914
Molecular Function:
primary active transporter
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