This antibody detects endogenous protein at a molecular weight of 52 kDa.
Purity is >95% by SDS-PAGE.
ATP6AP1 (ATPase, H+ transporting, lysosomal accessory protein 1), also known as 16A, CF2, Ac45, XAP3, ATP6S1, VATPS1 (vacuolar ATP synthase S1 accessory protein) or ATP6IP1, is a type I transmembrane, V-ATPase accessory protein that is predominantly expressed in endocrine and neuronal cells. ATP6AP1 is responsible for targeting the V-ATPase enzyme to specialized complex vacuolar systems. Via its cytoplasmic tail, ATP6AP1 interacts with subunits of the V0 domain. The disruption of this interaction in osteoclasts results in impaired bone resorption, suggesting an important role for ATP6AP1 in proper osteoclastic bone resorption.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATP6AP1; ATP6IP1; ATP6S1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; ATPase, H+ transporting, lysosomal interacting protein 1; H-ATPase subunit; Protein C7-1; Protein XAP-3; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit Ac45; V-ATPase subunit S1; V-type proton ATPase subunit S1; vacuolar H+ ATPase accessory subunit 1; Vacuolar proton pump subunit S1; VATPS1; XAP3
Gene Aliases: 16A; AC45; AI316502; ATP6AP1; ATP6IP1; ATP6S1; AW108110; C7-1; CF2; mFLJ00383; VATPS1; XAP-3; XAP3