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Product Details
13828-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATP6V0A1 Fusion Protein Ag4191 (1-400 aa encoded by BC032398)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGELFRSEE MTLAQLFLQS EAAYCCVSEL GELGKVQFRD LNPDVNVFQR KFVNEVRRCE EMDRKLRFVE KEIRKANIPI MDTGENPEVP FPRDMIDLEA NFEKIENELK EINTNQEALK RNFLELTELK FILRKTQQFF DEMADPDLLE ESSSLLEPSE MGRGTPLRLG FVAGVINRER IPTFERMLWR VCRGNVFLRQ AEIENPLEDP VTGDYVHKSV FIIFFQGDQL KNRVKKICEG FRASLYPCPE TPQERKEMAS GVNTRIDDLQ MVLNQTEDHR QRVLQAAAKN IRVWFIKVRK MKAIYHTLNL CNIDVTQKCL IAEVWCPVTD LDSIQFALRR GTEHSGSTVP SILNRMQTNQ TPPTYNKTNK FTYGFQNIVD AYGIGTYREI NPAPYTIITF P (1-400 aa encoded by BC032398)
Target Information
ATP6V0A1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adenosine triphosphatase; ATPase H+ transporting lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD); ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1A (110/160 kDa); ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); ATPase, H+ transporting, lysosomal noncatalytic accessory protein 1a; ATPase, H+ transporting, lysosomal V0 subunit a; ATPase, H+ transporting, lysosomal V0 subunit a1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; V-A; V-ATPase 116 kDa; V-ATPase 116 kDa subunit a 1; V-ATPase a1; v-H+ATPase subunit a1; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a 1; V-type proton ATPase 116 kDa subunit a isoform 1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1; vacuolar-type H(+)-ATPase 115 kDa subunit
Gene Aliases: a1; AA959968; ATP6a1; ATP6N1; ATP6N1A; ATP6V0A1; Atpv0a1; Stv1; Vph1; Vpp-1; VPP1
UniProt ID: (Human) Q93050, (Mouse) Q9Z1G4, (Rat) P25286
Entrez Gene ID: (Human) 535, (Mouse) 11975, (Rat) 29757
vacuolar acidification
insulin receptor signaling pathway
ATP synthesis coupled proton transport
ATP hydrolysis coupled proton transport
regulation of macroautophagy
transferrin transport
ion transmembrane transport
vacuolar proton-transporting V-type ATPase complex assembly
phagosome acidification
toxin transport
transport
ion transport
proton transport
biological_process
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