Invitrogen

ATP6V0D2 Polyclonal Antibody

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ATP6V0D2 Antibody in Western Blot (WB) — Western blot analysis of transfected 293T cells using an anti-ATP6V0D2 polyclonal antibody (Product # PA5-44359).

Product Details

PA5-44359

Applications	Tested Dilution	Publications
Western Blot (WB)	0.2-1 µg/mL	View 2 publications 2 publications
Immunohistochemistry (IHC)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide directed towards the middle region of human ATP6V0D2
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Purification	Affinity Chromatography
Storage buffer	PBS with 2% sucrose
Contains	0.09% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2606627

Product Specific Information

Peptide sequence: GLRLLAQAED FDQMKNVADH YGVYKPLFEA VGGSGGKTLE DVFYEREVQM

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Target Information

ATP6V0D2 is the subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. ATP6V0D2 may play a role in coupling of proton transport and ATP hydrolysis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.

Nature communications

Place DE,Malireddi RKS,Kim J,Vogel P,Yamamoto M,Kanneganti TD

PA5-44359 was used in Western Blotting to investigate the effects of reduced IFN signalling components on bone density and osteoclasyogenesis in mice.

Thu Jan 21 00:00:00 EST 2021

A20 inhibits osteoclastogenesis via TRAF6-dependent autophagy in human periodontal ligament cells under hypoxia.

Cell proliferation

Yan K,Wu C,Ye Y,Li L,Wang X,He W,Ren S,Xu Y

PA5-44359 was used in Western Blot to suggest that A20 may be a key gene target during bone loss in periodontitis via TRAF6-mediated inhibition of autophagy.

Sun Mar 01 00:00:00 EST 2020

A20 inhibits osteoclastogenesis via TRAF6-dependent autophagy in human periodontal ligament cells under hypoxia.

Cell proliferation

Yan K,Wu C,Ye Y,Li L,Wang X,He W,Ren S,Xu Y

PA5-44359 was used in Western Blot to suggest that A20 may be a key gene target during bone loss in periodontitis via TRAF6-mediated inhibition of autophagy.

Sun Mar 01 00:00:00 EST 2020

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.

Nature

Montoro DT,Haber AL,Biton M,Vinarsky V,Lin B,Birket SE,Yuan F,Chen S,Leung HM,Villoria J,Rogel N,Burgin G,Tsankov AM,Waghray A,Slyper M,Waldman J,Nguyen L,Dionne D,Rozenblatt-Rosen O,Tata PR,Mou H,Shivaraju M,Bihler H,Mense M,Tearney GJ,Rowe SM,Engelhardt JF,Regev A,Rajagopal J

PA5-44359 was used in Immunohistochemistry-immunofluorescence to combine single-cell RNA-seq and in vivo lineage tracing to study the cellular composition and hierarchy of the murine tracheal epithelium.

Wed Aug 01 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2; FLJ38708; V-ATPase subunit d 2; V-type proton ATPase subunit d 2; Vacuolar proton pump subunit d 2

Gene Aliases: ATP6D2; ATP6V0D2; VMA6

UniProt ID: (Human) Q8N8Y2

Entrez Gene ID: (Human) 245972

Molecular Function: ATP synthase