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Proteintech
ATP6V1B1 Polyclonal Antibody
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Product Details
14780-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATP6V1B1 Fusion Protein Ag6332 (1-327 aa encoded by BC063411)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAMEIDSRP GGLPGSSCNL GAAREHMQAV TRNYITHPRV TYRTVCSVNG PLVVLDRVKF AQYAEIVHFT LPDGTQRSGQ VLEVAGTKAI VQVFEGTSGI DARKTTCEFT GDILRTPVSE DMLGRVFNGS GKPIDKGPVV MAEDFLDING QPINPHSRIY PEEMIQTGIS PIDVMNSIAR GQKIPIFSAA GLPHNEIAAQ ICRQAGLVKK SKAVLDYHDD NFAIVFAAMG VNMETARFFK SDFEQNGTMG NVCLFLNLAN DPTIERIITP RLALTTAEFL AYQCEKHVLV ILTDMSSYAE ALREVSAARE EVPGRRGFPG YMYTDLAT (1-327 aa encoded by BC063411)
Target Information
Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A-H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. The V-ATPase V1 B subunit exists as two isoforms. In the inner ear, the V-ATPase B1 isoform functions in proton secretion and is required to maintain proper endolymph pH and normal auditory function. The gene encoding the human V-ATPase B1 isoform maps to chromosome 2cen-q13. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. The V-ATPase B2 isoform is expressed in kidney and is the only B isoform expressed in osteoclasts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1; ATPase, H+ transporting, V1 subunit B, isoform 1; Endomembrane proton pump 58 kDa subunit; H(+)-transporting two-sector ATPase, 58kD subunit; H+-ATPase beta 1 subunit; lysosomal 56/58kDa; proton pump 58 kDa subunit; unnamed protein product; V-ATPase B1; V-ATPase B1 subunit; V-ATPase subunit B 1; V-type proton ATPase subunit B, kidney isoform; vacuolar proton pump 3; Vacuolar proton pump subunit B 1; vacuolar proton pump, subunit 3
Gene Aliases: ATP6B1; ATP6V1B1; AW208839; D630003L15; D630030L16Rik; D630039P21Rik; DRTA2; RTA1B; VATB; VMA2; Vpp-3; VPP3
UniProt ID: (Human) P15313, (Mouse) Q91YH6
Entrez Gene ID: (Human) 525, (Rat) 312488, (Mouse) 110935
nucleotide binding
protein binding
ATP binding
hydrogen ion transmembrane transporter activity
macromolecular complex binding
proton-transporting ATPase activity, rotational mechanism
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
protein complex binding
ATP synthase
ossification
renal water homeostasis
renal sodium ion transport
prostaglandin metabolic process
ion transport
regulation of pH
vacuolar acidification
sensory perception of sound
regulation of gene expression
regulation of macroautophagy
adult behavior
renal sodium excretion
olfactory behavior
inner ear morphogenesis
pH reduction
ATP metabolic process
chloride ion homeostasis
calcium ion homeostasis
potassium ion homeostasis
vacuolar proton-transporting V-type ATPase complex assembly
renal tubular secretion
synaptic vesicle lumen acidification
hydrogen ion transmembrane transport
excretion
biological_process
ATP hydrolysis coupled proton transport
proton transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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