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Immunogen sequence: CRIYPEEMI QTGISAIDGM NSIARGQKIP IFSAAGLPHN EIAAQICRQA GLVKKSKDVV DYSEENFAIV FAAMGVNMET ARFFKSDFEE NGSMDNVCLF LNLANDPTIE RIITPRLALT TAEFLAYQCE KHVLVILTDM SSYAEALREV SAAREEVPGR RGFPGYMYTD LATIYERAGR VEGRNGSITQ IPILTMPNDD ITHPIPDLTG YITEGQIYVD RQLHNRQIYP PINVLPSLSR LMKSAIGEGM TRKDHADVSN QLYACYAIGK DVQAMKAVVG EEALTSDDLL YLEFLQKFER NFIAQGPYEN RTVFETLDIG WQLLRIFPKE MLKRIPQSTL SEFYPRDSAK H (162-511 aa encoded by BC003100)
ATP6V1B2 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.
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Protein Aliases: ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2; ATPase, H+ transporting, lysosomal 56/58kD, V1 subunit B, isoform 2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2; ATPase, H+ transporting, V1 subunit B, isoform 2; Endomembrane proton pump 58 kDa subunit; H+ transporting two-sector ATPase; HO57; lysosomal 56/58kDa; testicular secretory protein Li 65; V-ATPase B2 subunit; V-ATPase subunit B 2; V-type proton ATPase subunit B, brain isoform; vacuolar H+-ATPase 56,000 subunit; vacuolar H+ATPase B2; Vacuolar proton pump subunit B 2
Gene Aliases: AI194269; AI790362; ATP6B1B2; ATP6B2; ATP6V1B2; DOOD; HO57; R74844; Vat2; VATB; Vma2; VPP3; ZLS2
Molecular Function: ATP synthase