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Invitrogen
ATP7A Polyclonal Antibody
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FIGURE: 1 / 1
ATP7A Antibody (PA1-20840) in WB
Western blot of ATP7A in E. coli derived fusion protein using an ATP7A polyclonal antibody (Product # PA1-20840) at a dilution of 1:2000 followed by detection using a Goat anti-IgY-HRP secondary antibody at a dilution of 1:1000 and Colorimetric signal development.
Product Details
PA1-20840
Product Specifications
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment, corresponding to amino acids 1407-1500 of Human ATP7A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
PA1-20840 detects ATP7A in human, mouse and rat samples.
PA1-20840 has been successfully used in Western blot procedures.
The PA1-20840 immunogen is a recombinant fragment, corresponding to amino acids 1407-1500 of Human ATP7A..
Target Information
ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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