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Search Thermo Fisher Scientific
Immunogen sequence: TETLGTCIDF QVVPGCGISC KVTNIEGLLH KNNWNIEDNN IKNASLVQID ASNEQSSTSS SMIIDAQISN ALNAQQYKVL IGNREWMIRN GLVINNDVND FMTEHERKGR TAVLVAVDDE LC
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 84%.
ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood.
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Protein Aliases: ATP 7A; ATPase, Cu++ transporting, alpha polypeptide; Copper pump 1; Copper-transporting ATPase 1; Cu++-transporting P-type ATPase; FLJ17790; MC 1; Menke; Menkes disease-associated protein; Menkes syndrome; OHS; OTTHUMP00000062077
Gene Aliases: ATP7A; DSMAX; MC1; MK; MNK; SMAX3
UniProt ID: (Human) Q04656
Entrez Gene ID: (Human) 538
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